Evidence map›Paper›PMID 40576318›Full record

ArticleAnnals of medicine2025

Association between heavy metal exposure and chronic cough: the mediating roles of inflammation.

Jun Wen, Rongjuan Zhuang, Qin Zhang, Changfen Wang, Jing Chi

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Article in Annals of medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

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3 · Its place in the literature

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1 citing paper in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Jun WenDepartment of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing Medical University, Chongqing, China.ORCID 0000-0002-2678-7329
Rongjuan ZhuangDepartment of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing Medical University, Chongqing, China.
Qin ZhangDepartment of Cardiology, Xi Chang People's Hospital, Xi Chang, Sichuan Province, China.
Changfen WangDepartment of Cardiology, People's Hospital of Qianxinan Prefecture, Guizhou Province, China.
Jing ChiDepartment of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing Medical University, Chongqing, China.ORCID 0000-0002-2516-2247

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundRight now, epidemiological research examining the connection between blood heavy metal exposure and chronic coughing is still deficient. Therefore, the survey was aimed at the effects of multiple heavy metals on chronic cough.

methodIn this investigation, 2647 individuals from NHANES were included. This study applied multiple statistical models to systematically explore the associations between single and mixed blood metal with the prevalence of chronic cough, including logistic regression, weighted quantile sum (WQS) regression, bayesian kernel machine regression (BKMR), and the Shapley Additive Explanations (SHAP) model. Finally, this research conducted mediation analyses to investigate the mediated effects of inflammation on the association between metal and chronic cough.

resultIn the logistic regression model of single exposure, blood cadmium was positively associated with the prevalence of chronic cough (OR: 3.17; 95% CI: 2.08-4.83). Consistent findings from the WQS, BKMR, and SHAP models revealed that cumulative exposure to multiple blood metals was positively linked to chronic cough, with cadmium emerging as the predominant contributor among the five examined metals. Mediation analyses indicated that WBC and neutrophils, with a proportion of 2.74% and 5.06%, respectively, mediated the link of cadmium in blood with chronic cough.

conclusionExposure to heavy metal mixtures was linked to an increase in the prevalence of chronic cough. And blood cadmium may primarily drive this association, with activated inflammation partially mediating it. Our findings offer novel insights into the impact of blood cadmium to chronic cough.

Indexed as

CoughEnvironmental ExposureInflammationMetals, HeavyAdultAgedBayes TheoremCadmiumChronic CoughChronic DiseaseFemaleHumansLogistic ModelsMaleMiddle AgedNutrition SurveysCadmiumMetals, HeavyBayesian kernel machine regression (BKMR)chronic coughHeavy metalinflammationmediationShapley additive explanations (SHAP)

Identifiers

PMID40576318
PMCPMC12207769

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.