SynthesisNutrition reviews2026
The Impacts of Probiotics Supplementation on the Treatment of Periodontitis: An Umbrella Meta-Analysis.
Synthesis in Nutrition reviews, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- Efficacy of a Microencapsulated Sugar-Free Probiotic Oral Rinse on Gingival Health and Salivary Matrix Metalloproteinases 8 and 9 in Children With Down Syndrome: A Pilot Randomized Clinical Trial.Special care in dentistry : official publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric DentistryTrial
- Oral Supplementation ofDentistry journal · 2026Article
- Review
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
contextProbiotics supplementation has many beneficial impacts on periodontitis outcomes.
objectiveThis umbrella meta-analysis evaluated the effectiveness of probiotics in treating periodontitis, focusing on primary outcome measures, including reductions in probing pocket depth (PPD), clinical attachment level (CAL), bleeding on probing (BOP), plaque index (PI), gingival index (GI), and PDD reduction in medium and deep pockets. DATA SOURCE: The Scopus, PubMed, Web of Science, Embase, and Google Scholar online databases were searched up to January 2024. DATA EXTRACTION: All meta-analyses evaluating the impact of probiotics supplementation on periodontitis outcomes were considered eligible. DATA ANALYSIS: A random-effects model was employed to estimate the pooled results. Subgroup and sensitivity analyses were conducted. The quality of the studies was evaluated using the AMSTAR2 tool. Overall, 19 meta-analyses with 67 data sets were included in this umbrella review. Our findings indicated that probiotics supplementation significantly decreased BOP (effect size [ES]: -8.20; 95% CI: -15.10 to -1.31; P = .02) and CAL after sensitivity analysis (ES: -0.52; 95% CI: -0.75 to -0.28; P < .05). No other significant effect was observed on PPD, PI, GI, or PDD reduction in medium and deep pockets.
conclusionThis umbrella meta-analysis found that, during their treatment process, probiotics supplementation may positively affect BOP and CAL in people with periodontitis.
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Registered trials
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