Evidence map›Paper›PMID 40576133›Full record

ArticleInternational journal of molecular medicine2025

GW8510 alleviates muscle atrophy and skeletal muscle dysfunction in mice through AMPK/PGC1α signaling.

Yutong Chen, Zurui Liu, Chen Liu, Daqian Yang, Mengmeng Xiao, Zhengqian Li, Zhengwei Xie

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yutong ChenPeking University International Cancer Institute, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, P.R. China.
Zurui LiuBeijing Gigaceuticals Tech. Co. Ltd., Beijing 102206, P.R. China.
Chen LiuBeijing Gigaceuticals Tech. Co. Ltd., Beijing 102206, P.R. China.
Daqian YangPeking University International Cancer Institute, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, P.R. China.
Mengmeng XiaoPeking University International Cancer Institute, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, P.R. China.
Zhengqian LiPeking University International Cancer Institute, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, P.R. China.
Zhengwei XiePeking University International Cancer Institute, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, P.R. China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Preventing and restoring muscle loss and function is essential for elderly individuals. GW8510 may accelerate myotube differentiation. The present study aimed to investigate the protective effect of GW8510 (a CDK2 inhibitor) on muscle atrophy. Mouse models of muscle atrophy were induced by denervation, dexamethasone and glycerol. Muscle‑to‑body weight ratio, the cross‑sectional area of muscles, grip strength, fatigue and serum levels of superoxide dismutase and creatine kinase were assessed.

Indexed as

AMP-Activated Protein KinasesMuscle, SkeletalMuscular AtrophyPeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaSignal TransductionAnimalsCell LineDexamethasoneDisease Models, AnimalMaleMiceMice, Inbred C57BLMitochondriaMuscle Fibers, SkeletalReactive Oxygen SpeciesAMP-Activated Protein KinasesDexamethasonePeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaPpargc1a protein, mouseReactive Oxygen SpeciesAMPKdenervationdexamethasoneGW8510muscle atrophyPgc1α

Identifiers

PMID40576133
PMCPMC12236748

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.