Evidence map›Paper›PMID 40575982›Full record

ArticleAnimal bioscience2025

Effects of dietary sodium butyrate supplementation on fat metabolism in lamb adipose and liver tissues.

Yue Zhang, Hongbo Qu, Yueying Guo, Mirco Corazzin, Min Zhang, Ting Liu, Lin Su, Lihua Zhao, Lina Sun, Ye Jin

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In one paragraph

Article in Animal bioscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Yue ZhangCollege of Food Science and Engineering, Inner Mongolia Agricultural University, Hohhot, China.
Hongbo QuCollege of Food Science and Engineering, Inner Mongolia Agricultural University, Hohhot, China.
Yueying GuoCollege of Food Science and Engineering, Inner Mongolia Agricultural University, Hohhot, China.
Mirco CorazzinDepartment of Agricultural, Food, Environmental and Animal Sciences, University of Udine, Udine, Italy.
Min ZhangCollege of Food Science and Engineering, Inner Mongolia Agricultural University, Hohhot, China.
Ting LiuCollege of Food Science and Engineering, Inner Mongolia Agricultural University, Hohhot, China.
Lin SuCollege of Food Science and Engineering, Inner Mongolia Agricultural University, Hohhot, China.
Lihua ZhaoCollege of Food Science and Engineering, Inner Mongolia Agricultural University, Hohhot, China.
Lina SunCollege of Food Science and Engineering, Inner Mongolia Agricultural University, Hohhot, China.
Ye JinCollege of Food Science and Engineering, Inner Mongolia Agricultural University, Hohhot, China.

Funding

Basic research funds for universities directly under the Inner Mongolia Autonomous Region BR221306Basic research funds for universities directly under the Inner Mongolia Autonomous Region BR230165Central Guides Local Science and Technology Development Foundation 2022ZY0029Major R&D and Achievements Transformation Projects of Inner Mongolia 2022YFXZ0017National Natural Science Foundation of China 32160589Natural Science Foundation of Inner Mongolia 2022MS03055
6 · The paper itself

Abstract

objectiveSodium butyrate (SB) is a potentially useful feed additive; however, its effects on lipid metabolism in adipose and liver tissues of lambs are still not fully explored. This study systematically examined the effects and underlying mechanisms of dietary SB supplementation on lipid metabolism in lamb adipose and liver tissues from an adipose-blood-liver perspective.

methodsTwelve 3-month-old male lambs (22.37±2.05 kg) were randomly divided into a control group and an SB group. We measured the adipose tissue cellular morphology and lipid metabolism-related indices in both adipose and liver tissues.

resultsThe results indicated that SB significantly reduces abdominal and perirenal adipose tissue mass, as well as the average area and diameter of adipocytes (p<0.05). Dietary supplementation with SB activated adenosine 5'-monophosphate-activated protein kinase α1 (AMPKα1) in lamb adipose tissue, resulting in upregulated mRNA expression of hormone-sensitive triglyceride lipase (HSL) and downregulated mRNA expression of sterol regulatory element-binding protein 1 and fatty acid synthase (p<0.05). Simultaneously, adiponectin secretion and receptor expression in adipose tissue, as well as serum adiponectin levels, were significantly elevated (p<0.05). Moreover, dietary supplementation with SB increased the levels of tricarboxylic acid cycle metabolites in lamb liver, including oxaloacetate, citrate, cis-aconitate, and succinate (p<0.05), while simultaneously activating the liver AMPKα1 signaling pathway. These changes led to upregulated HSL, platelet glycoprotein 4, and long-chain acyl-CoA synthetase mRNA expression (p<0.05), thereby enhancing liver fatty acid metabolism.

conclusionIn summary, dietary supplementation with SB alters adiponectin levels in lambs, activates the AMPK signaling pathway, promotes adipose tissue lipolysis, and regulates liver lipid metabolism. The findings provide valuable insights into the use of SB for managing lamb body fat reserves and offer a robust basis for further research in animal bioscience.

Indexed as

Adipose-liver AxisFat DistributionLamb Adipose TissueNutritional RegulationSodium Butyrate

Identifiers

PMID40575982
PMCPMC12580741

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