ArticleFrontiers in pharmacology2025
Understanding the molecular basis of herbal medicines for cough variant asthma under the guidance of traditional herbal theories.
Article in Frontiers in pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Article
- HerbComb: An integrated database for the discovery of novel combinational therapies from herbal medicines.Computational and structural biotechnology journal · 2025Article
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8 authors.
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Abstract
Introduction: Despite the clear clinical efficacy of the herbal formula Methods: To address this gap, we proposed a novel computational paradigm to understand how herbal medicines exert therapeutic effects on CVA under the guidance of TCM theories. Our approach integrates transcriptional perturbation data, graph neural network (GNN) models, and network proximity analysis, enabling the interpretation of herbal actions within a network pharmacology context. Results: We found that traditional herbal theories show strong molecular-level associations with therapeutic mechanisms: 1) Meridian classifications of herbs align with their gene perturbation profiles across different organs; 2) Herbal combinations and their therapeutic efficacy correlate with the network proximity of their targets to disease-specific genes. Notably, network proximity analysis revealed mechanistic support for key TCM concepts such as the Discussion: This study presents a novel framework for interpreting the molecular basis of herbal medicines and their combinations under TCM theory guidance.
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