Evidence map›Paper›PMID 40575655›Full record

ArticleMaterials today. Bio2025

NIR light-propelled Janus Polydopamine@Mesoporous silica gene delivery nanomotor for the enhanced gene treatment of critical limb ischemia.

Liang Gui, Suyu Wang, Suyu Miao, Minghang Qiao, Yuanyong Jiao, Haibin Chen, WanYang Li, Junjie Zou, Xin Du

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials today. Bio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Liang GuiDepartment of Vascular Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, 210029, China.
Suyu WangDepartment of Endocrinology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, 210029, China.
Suyu MiaoDepartment of Vascular Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, 210029, China.
Minghang QiaoBeijing Key Laboratory for Bioengineering and Sensing Technology, School of Chemistry and Biological Engineering, University of Science & Technology Beijing, Beijing, 100083, China.
Yuanyong JiaoDepartment of Vascular Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, 210029, China.
Haibin ChenDepartment of Vascular Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, 210029, China.
WanYang LiDepartment of Nutrition, Qilu Hospital of Shandong University, Jinan, Shandong, 250012, China.
Junjie ZouDepartment of Vascular Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, 210029, China.
Xin DuBeijing Key Laboratory for Bioengineering and Sensing Technology, School of Chemistry and Biological Engineering, University of Science & Technology Beijing, Beijing, 100083, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Among multiple non-invasive therapeutic approaches for critical limb ischemia (CLI), gene therapy has been widely researched because of its capacity to ensure continuous expression and growth factors release. Hypoxia-inducible factor-1α (HIF-1α), a gene that can promote stable angiogenesis and tissue restoration, is a potential candidate for facilitating cellular adaptation to hypoxia during vascular injury recovery. Herein, we designed a near-infrared (NIR) light-propelled pEX-1/HIF-1α plasmid DNA (pDNA) loaded Janus polydopamine@mesoporous silica (PDA@MS) nanomotors (PDA@MS-NH

Indexed as

Asymmetric yolk@shellGene therapyHindlimb ischemiaNanomotorsPolydopamine

Identifiers

PMID40575655
PMCPMC12198028

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.