Evidence map›Paper›PMID 40575587›Full record

ArticleInternational journal of nephrology2025

An Exploratory Single-Arm Clinical Trial on Eucommia Ulmoides Leaf Extract Effects on Blood Pressure, Oxidative Stress, and Atrial Natriuretic Peptide (ANP) in Individuals With and Without Chronic Kidney Disease.

Hiroshi Satonaka, Shohei Yokoyama, Akira Ishimitsu, Chisato Takahashi, Tatemitsu Rai, Daisuke Nagata, Toshihiko Ishimitsu, Akihiro Tojo

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of nephrology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Hiroshi SatonakaDivision of Nephrology, Department of Internal Medicine, Jichi Medical University, 3311-1, Yakushi-ji, Shimotsuke-shi, Tochigi 329-0498, Japan.ORCID https://orcid.org/0009-0009-6473-3004
Shohei YokoyamaDepartment of Nephrology and Hypertension, Dokkyo Medical University, 880, Kitakobayashi, Mibu, Shimotsuga-gun, Tochigi 321-0293, Japan.
Akira IshimitsuDepartment of Nephrology and Hypertension, Dokkyo Medical University, 880, Kitakobayashi, Mibu, Shimotsuga-gun, Tochigi 321-0293, Japan.
Chisato TakahashiDepartment of Nephrology and Hypertension, Dokkyo Medical University, 880, Kitakobayashi, Mibu, Shimotsuga-gun, Tochigi 321-0293, Japan.
Tatemitsu RaiDepartment of Nephrology and Hypertension, Dokkyo Medical University, 880, Kitakobayashi, Mibu, Shimotsuga-gun, Tochigi 321-0293, Japan.
Daisuke NagataDivision of Nephrology, Department of Internal Medicine, Jichi Medical University, 3311-1, Yakushi-ji, Shimotsuke-shi, Tochigi 329-0498, Japan.
Toshihiko IshimitsuDepartment of Nephrology and Hypertension, Dokkyo Medical University, 880, Kitakobayashi, Mibu, Shimotsuga-gun, Tochigi 321-0293, Japan.
Akihiro TojoDepartment of Nephrology and Hypertension, Dokkyo Medical University, 880, Kitakobayashi, Mibu, Shimotsuga-gun, Tochigi 321-0293, Japan.ORCID https://orcid.org/0000-0002-9315-7546

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Eucommia ulmoides (Tochu) has been shown to possess a variety of beneficial effects on profiles affecting the onset of lifestyle- or aging-related diseases, such as hypertension, diabetes, dyslipidemia, or obesity. This exploratory single-arm clinical study was conducted on a total of 17 participants including those with mild chronic kidney disease (CKD) (

Identifiers

PMID40575587
PMCPMC12202076

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.