Evidence map›Paper›PMID 40575584›Full record

ArticleFrontiers in veterinary science2025

Comparative analysis of IscM and IscQu in feline oral squamous cell carcinoma treatment: cytotoxic and apoptotic insights.

Huseyin Cakiroglu, Asuman Deveci Ozkan, Gulay Erman, Mehmet Fatih Bozkurt, Sevinc Yanar, Elif Kale Bakir, Yonca Yuzugullu Karakus

Abstract read
In one paragraph

Article in Frontiers in veterinary science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Huseyin CakirogluExperimental Medicine Research and Application Centre, Sakarya University, Sakarya, Türkiye.
Asuman Deveci OzkanDepartment of Medical Biology, Faculty of Medicine, Sakarya University, Sakarya, Türkiye.
Gulay ErmanHealth Services Education Research and Application Centre, Sakarya University, Sakarya, Türkiye.
Mehmet Fatih BozkurtDepartment of Pathology, Faculty of Veterinary Medicine, Afyon Kocatepe University, Afyon, Türkiye.
Sevinc YanarDepartment of Histology and Embryology, Faculty of Medicine, Sakarya University, Sakarya, Türkiye.
Elif Kale BakirDepartment of Biology, Institute of Science, Kocaeli University, Kocaeli, Türkiye.
Yonca Yuzugullu KarakusDepartment of Biology, Faculty of Science and Art, Kocaeli University, Kocaeli, Türkiye.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Backround: Feline oral squamous cell carcinoma (FOSCC) is the most common malignant oral tumor in cats, characterized by invasive and aggressive behavior regardless of its location. Conventional treatments, including surgery, radiation therapy, and chemotherapy, often yield unsatisfactory outcomes, with tumor progression and tissue destruction frequently leading to euthanasia. In anthroposophical medicine, extracts of Methods: Using primary cultures of three FOSCC cell lines, cell viability assays were performed to assess cytotoxicity, and the effects on apoptotic cell death, cell cycle arrest, and cellular and nuclear morphology were evaluated. Additionally, mRNA expression levels of Results: The results revealed that both IscM and IscQu induced apoptotic cell death and promoted cell cycle arrest in all three FOSCC cell lines tested. IscQu exhibited relatively stronger pro-apoptotic effects compared to IscM, although no significant differences were observed among the cell lines. Conclusion: These findings suggest that

Indexed as

anticancer effectapoptosisfeline squamous cell carcinomaiscadorViscum album

Identifiers

PMID40575584
PMCPMC12199264

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.