ArticleFrontiers in medicine2025
Dual locking plate fixation, PRP-augmented autologous bone grafting, and bioactive core construction for femoral fracture nonunion: a retrospective study of 52 cases.
Article in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Article
- A 1:1 matched-pair comparative study of minimally invasive elastic Poller wire augmentation vs. standard augmentative plating for hypertrophic femoral non-union after intramedullary nailing.Frontiers in medicine · 2026Article
- Effect of Osteoperiosteal Decortication With Bone Grafting on Healing of Femoral Fracture Nonunion.Case reports in orthopedics · 2026Article
- Platelet-rich plasma enhanced therapy for aseptic atrophic tibial diaphyseal nonunion: a single-center retrospective controlled study of 90 cases.Journal of orthopaedic surgery and research · 2025Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Femoral nonunion remains a challenging orthopedic condition. This study evaluates a combined protocol integrating biomechanical stabilization (dual locking plate fixation) and maximal biological stimulation (PRP-augmented autologous bone grafting with bioactive core construction) to optimize bone healing. Methods: A retrospective analysis included 52 femoral nonunion patients treated at a tertiary trauma center (2020-2024). Outcomes assessed radiographic union (9-month and final follow-up), clinical union time, thigh incision healing, pain scores (VAS), lower extremity function (LEFS), and complications. Results: Cohort demographics: 35 males, 17 females; mean age 41.38 years, BMI 24.79 kg/m Conclusion: The protocol demonstrated efficacy and safety, achieving rapid union (6.56 months), robust functional recovery (LEFS 63.92), and a low incidence of serious complications (3.85%). Biomechanical-biological integration represents a viable strategy for femoral nonunion management.
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