Evidence map›Paper›PMID 40575527›Full record

ArticleJournal of education and health promotion2025

Age-dependent nonlinear relationship between hypertension and hippocampal volume in sedentary women with lower educational attainment.

Sneha Ravichandran, Poovitha Shruthi Paramashiva, Rajagopal Kadavigere, Hari Prakash Palanisamy, K N Shivashankar, Baskaran Chandrasekaran, M G Ramesh Babu, Winniecia Dkhar, Dilip Shettigar, Sathya Sabina Muthu and 1 more

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Article in Journal of education and health promotion, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Sneha RavichandranDepartment of Medical Imaging Technology, Manipal College of Health Professions Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, India.
Poovitha Shruthi ParamashivaDivision of Yoga, Centre for Integrative Medicine and Research, Manipal Academy of Higher Education, Manipal, Karnataka, India.
Rajagopal KadavigereDepartment of Radiodiagnosis and Imaging, Kasturba Medical College Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, India.
Hari Prakash PalanisamyDepartment of Speech and Hearing, MCHP, MAHE, Manipal, Karnataka, India.
K N ShivashankarDepartment of Medicine, Kasturba Medical College Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, India.
Baskaran ChandrasekaranDepartment of Exercise and Sports Sciences, Manipal College of Health Professions Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, India.
M G Ramesh BabuDepartment of Basic Medical Sciences, Manipal Academy of Higher Education, Manipal, Karnataka, India.
Winniecia DkharDepartment of Medical Imaging Technology, Manipal College of Health Professions Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, India.
Dilip ShettigarDepartment of Medical Imaging Technology, Manipal College of Health Professions Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, India.
Sathya Sabina MuthuDepartment of Medical Imaging Technology, Manipal College of Health Professions Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, India.
Suresh SukumarDepartment of Medical Imaging Technology, Manipal College of Health Professions Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThis study investigated the age-dependent nonlinear relationship between hypertension stages, hippocampal volume, and cognitive performance in sedentary women with lower educational attainment. MATERIALS AND

methodsForty-four women (40-60 years) with low education and physical activity levels underwent Magnetic Resonance Imaging brain scans and cognitive tests. Hippocampal volumes were analyzed using CAT12 and SPM12.

resultsAge-dependent relationships between systolic blood pressure (SBP) and hippocampal volume were observed. In ages 40-49, higher SBP correlated with more minor left hippocampal volumes (r = -0.5937,

conclusionThese findings challenge the "lower is better" blood pressure paradigm, especially in older adults, suggesting the need for age-specific hypertension management and brain health preservation strategies. Public health implications include developing tailored interventions considering age, education, and physical activity; implementing age-specific blood pressure guidelines; integrating cognitive screenings into hypertension care; and creating targeted health literacy programs. Future research should establish causality, explore mechanisms, and evaluate personalized strategies for this vulnerable population.

Indexed as

Agingbraincardiovascular risk factorscognitionhippocampushypertensionmagnetic resonance imagingneuroimagingpublic healthsedentary behaviorwomen’s health

Identifiers

PMID40575527
PMCPMC12199997

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.