Evidence map›Paper›PMID 40575489›Full record

ArticleFrontiers in cellular and infection microbiology2025

Genomic evolution and dissemination of non-conjugative virulence plasmid of ST65 carbapenem-resistant and hypervirulent

Dongxing Tian, Mingqi Zhao, Lihua Liu, Shuhua Lu, Haixin Dong

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Dongxing TianDepartment of Clinical Laboratory, Affiliated Hospital of Jining Medical University, Jining, Shandong, China.
Mingqi ZhaoAffiliated Hospital of Jining Medical University, Jining, Shandong, China.
Lihua LiuDepartment of Clinical Laboratory, Affiliated Hospital of Jining Medical University, Jining, Shandong, China.
Shuhua LuDepartment of Clinical Laboratory, Affiliated Hospital of Jining Medical University, Jining, Shandong, China.
Haixin DongDepartment of Clinical Laboratory, Affiliated Hospital of Jining Medical University, Jining, Shandong, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The global rise in infections caused by hypervirulent and carbapenem-resistant Methods: Two clinical K2-ST65 CR-hvKp isolates (P6 and P10) were identified. Plasmid conjugation experiments were performed to assess the dissemination of the virulence plasmid. Antimicrobial susceptibility testing and virulence assays, including serum resistance, siderophore production, and Results: Genomic analyses showed that both P6 and P10 carry a non-conjugative virulence plasmid, a conjugative untyped KPC plasmid, and a conjugative IncM2 plasmid. These isolates displayed broad-spectrum anti-microbial resistance and multiple virulence phenotypes, although they failed to sustain both hypervirulence and carbapenem resistance over time. The IncM2 plasmid was shown to be essential for the transfer of non-conjugative virulence plasmid. Mechanistic studies highlighted IS Conclusions: This study provides new insights into the genomic dynamics of ST65-CR-hvKp strains and uncovers key mechanisms, such as IS

Indexed as

Carbapenem-Resistant EnterobacteriaceaeEvolution, MolecularKlebsiella InfectionsKlebsiella pneumoniaePlasmidsAnimalsAnti-Bacterial AgentsCarbapenemsChinaConjugation, GeneticDrug Resistance, Multiple, BacterialGenome, BacterialGenomicsHospitalsHumansMicrobial Sensitivity TestsAnti-Bacterial AgentsCarbapenemsVirulence Factorscarbapenem resistancehypervirulenceKlebsiella pneumoniaeplasmid transmissionST65

Identifiers

PMID40575489
PMCPMC12198223

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.