ReviewLaryngoscope investigative otolaryngology2025
Effects of Essential Oils in the Treatment of Acute Rhinosinusitis: A Systematic Review.
Review in Laryngoscope investigative otolaryngology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Effects of Essential Oils in the Treatment of Acute Rhinosinusitis: A Systematic Review.Laryngoscope investigative otolaryngology · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: Basic science studies have shown that essential oils have antibacterial and anti-inflammatory effects in the nasal mucosa. However, clinical studies examining the effect of essential oils on patient outcomes are limited. The aim of this systematic review is to evaluate the patient outcomes following treatment of acute rhinosinusitis with essential oils. Methods: PubMed, Ovid, Cochrane, and Embase computerized searches were performed to include results published up to December 2023. Two independent reviewers (C.M.M. and W.J.) conducted data extraction following a predetermined protocol, with any discrepancies reviewed by the senior author (J.C.W.). Results: Five RCTs investigated the treatment of rhinosinusitis with essential oils in capsule form. Essential oils included in the studies were Cineole, Myrtol (ELOM-080), Sinupret (BNO 1016), and Tavipec. Significant improvements in rhinological symptoms were seen in Cinole compared to placebo, Cinole compared to an herbal compound similar in composition to Sinupret, Tavipec compared to placebo, and ELOM-080 compared to placebo. Outcome measures included nasal obstruction, nasal drainage, facial pressure, headache, fatigue, and fever. Little difference in patient-reported rhinological symptom improvement was seen in ELOM-080 compared to BNO 1016 using a 5-point Likert Scale. Minimal adverse effects were observed in patients treated with essential oils with the most common adverse effect being mild gastrointestinal upset. Conclusion: Patients using essential oils reported improvement in acute rhinosinusitis symptoms in all studies reviewed, despite differences in methodology and outcome measures. These improvements were statistically significant in all the studies. Level of Evidence: Level 1 based on "The Oxford 2011 Levels of Evidence".
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.