ArticleJournal of oral biology and craniofacial research
Effect of fluoride toothpaste and mouthwash on the cytotoxicity of buccal mucosa cells in the presence of nickel-titanium archwires during comprehensive orthodontic treatment: A randomized clinical trial.
Article in Journal of oral biology and craniofacial research. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Cytotoxicity and Genotoxicity of Fluoride Toothpastes in Buccal Cells.Acta stomatologica Croatica · 2026Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: To evaluate the effect of fluoride on the cytotoxicity of buccal mucosa cells in the presence of nickel-titanium archwires. Materials and methods: Seventy-five subjects requiring comprehensive orthodontic treatment were randomly allocated to three groups. Healthy control group included normal subjects who did not receive orthodontic treatment. In the treatment control group, only stainless-steel attachments were placed without archwire. Experimental group included subjects in whom stainless-steel attachments and 0.014″ nickel-titanium archwires were used. Fluoride mouthwash and toothpaste were prescribed to all subjects. Buccal mucosa cell smear was assessed for cell viability, micronucleus scores and caspase-3 reactive cells just before (T Results: The buccal mucosa cell viability score was significantly lower in the experimental and treatment control groups than in the healthy control group subjects (P < 0.001). Micronucleus score was significantly higher in the experimental and treatment control groups compared to the healthy control group subjects (P < 0.001). The caspase-3 reactive cells and micronucleus scores were significantly more in the experimental group subjects compared to treatment control group subjects (P < 0.001). There was a negative but statistically non-significant correlation between cell viability and micronucleus score among three groups of subjects. Conclusion: The use of fluoride mouthwash and toothpaste in the presence of stainless-steel attachments and nickel-titanium archwire decreased the buccal cell viability by 8.51 % and increased the micronucleus score by 3.03 %. The use of fluoride toothpaste and mouthwash had a significant cytotoxicity effect on buccal mucosa cells in the presence of nickel-titanium archwire during comprehensive orthodontic treatment.
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