ArticleAsian biomedicine : research, reviews and news2025
Precocious puberty: a comprehensive review of diagnosis and clinical presentation, etiology, and treatment.
Article in Asian biomedicine : research, reviews and news, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
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Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Botanical drug preparations and related East Asian medicine interventions for central and idiopathic central precocious puberty: an umbrella review of systematic reviews and meta-analyses.Frontiers in pharmacology · 2026Pooled it
- Development of a parsimonious predictive model for height gain outcome in children with central precocious puberty following gonadotropin-releasing hormone agonist therapy.Translational pediatrics · 2026Article
- Gamma-aminobutyric acid supplementation combined with gonadotropin-releasing hormone analog therapy versus gonadotropin-releasing hormone analog therapy alone for linear growth in children with growth retardation: a retrospective cohort study.Translational pediatrics · 2026Article
- The diagnostic value and optimal cutoff of basal luteinizing hormone for central precocious puberty in premenarcheal girls stratified by weight status.Frontiers in endocrinology · 2026Article
- Parenting stress among parents of outpatients with precocious puberty: a cross-sectional survey.Frontiers in psychiatry · 2026Article
- Automated bone age assessment in rare pediatric growth disorders: a comparative study using Deeplasia.Frontiers in endocrinology · 2026Article
- The Diagnostic Utility of the Triptorelin Stimulation Test Compared to the Standard Gonadotropin-Releasing Hormone Stimulation Test in Children with Idiopathic Central Precocious Puberty.Diseases (Basel, Switzerland) · 2025Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Central precocious puberty (CPP) is characterized by early activation of the hypothalamic-pituitary-gonadal (HPG) axis, which is apparent in the form of breast development in girls and testicular enlargement in boys prior to the typical physiological age ranges. Although intracranial pathology, exposure to high levels of sex steroids, or environmental risk factors can precipitate CPP, the majority of cases are idiopathic. Monogenic causes have also been identified. We provide a concise summary of the pathophysiology, risk factors, diagnosis, and management of CPP in this review. A referral to pediatric endocrinology should be initiated when there is concern for CPP. The diagnosis is confirmed through clinical, biochemical, radiological, and genetic testing. The primary objectives of administering a gonadotropin-releasing hormone (GnRH) analog to patients with CPP are to increase adult height and postpone the development of secondary sexual characteristics until a later age that is more compatible with peer norms. Although the long-term results of treatment with GnRH analogs are encouraging, further research is required to investigate the psychological impact of CPP.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.