ArticleBioactive materials2025
AntagomiR-192-5p-engineered exosomes encapsulated in MXene-modified GelMA hydrogel facilitated epithelization of burn wounds by targeting OLFM4.
Article in Bioactive materials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Mesenchymal Stem Cell-Derived Extracellular Vesicles and Plant-Derived Nanovesicles as Cell-Free Therapies for Thermal Burn Healing: A Systematic Review of Preclinical Evidence and Delivery Strategies.Medical sciences (Basel, Switzerland) · 2026Pooled it
- Biomaterial-based extracellular vesicle delivery systems for wound healing: From fabrication to applications.Bioactive materials · 2026Review
- Paeonol-Loaded Cyclodextrin/Composite Hydrogel for Enhanced Transdermal Delivery and Skin Photoaging Repair.Gels (Basel, Switzerland) · 2026Article
- NIR-responsive smart hydrogel incorporating LF-decorated nanosheets recalibrating the immune-vascular-osteogenic microenvironment for enhanced bone regeneration.Journal of nanobiotechnology · 2026Article
- Intercellular Horizontal Transfer of TXNDC5 mRNA via Extracellular Vesicles Contributes to Tumor-Associated Macrophage-Mediated Prostate Cancer Metastasis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Exosomes in inflammatory tissue injury: key pathogenic factors and promising therapeutic agents.Frontiers in immunology · 2026Review
- Beyond wound closure: translational opportunities and barriers of mesenchymal stem cells and their extracellular vesicles in burn management.Frontiers in cell and developmental biology · 2026Review
- Construction of Smart Hydrogel-Exosome Drug Delivery Platforms and Their Applications in Skin Rehabilitation.International journal of nanomedicine · 2026Review
- [Performance of hyaluronic acid biogel and its effect on healing of infected burn wounds in mice].Zhonghua shao shang yu chuang mian xiu fu za zhi · 2025Article
- Synergistic potentials of small extracellular vesicles, biomaterials, and 3D bioprinting in periodontal regeneration: a scoping review.Extracellular vesicles and circulating nucleic acids · 2025Review
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Authors and funding
15 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Burn wound healing is a multifaceted process often complicated by excessive inflammation and impaired keratinocyte function, both of which are key factors contributing to delayed healing. In this study we screened the key miRNA regulating the epithelialization process under oxidative stress conditions through high-throughput sequencing. We identified that miR-192-5p was significantly upregulated in both oxidative stress models of keratinocytes and burn wound tissues, with detrimental effects on keratinocyte proliferation, migration, and apoptosis. Inhibition of miR-192-5p enhanced epidermal cell function by upregulating olfactomedin-4 (OLFM4), a key gene associated with cell proliferation, adhesion and migration. To optimize delivery and therapeutic efficacy, we engineered MSC-derived exosomes loaded with antagomiR-192-5p (ant-192; Final content: 2 nmol per wound; Loading efficiency: 35.22 ± 0.34 %) and then encapsulated into a composite hydrogel composed of GelMA and MXene (Ti
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