ArticleJACS Au2025
Harnessing (Phenylsulfonyl)difluoromethyl Sulfonium Salt: A Radical Approach to Photoredox-Catalyzed Functionalization of Unsaturated Compounds with the PhSO
Article in JACS Au, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A photoredox-catalyzed, modular method for the synthesis of versatile (phenylsulfonyl)-difluoromethylated compounds is presented. The key step in this transformation is the light-driven generation of a fluoroalkyl radical from our in-house-designed (phenylsulfonyl)-difluoromethyl sulfonium salt. Tuning the reactivity of this fluorinated sulfonium salt under photocatalysis provided an efficient tool for the direct functionalization of readily available olefins. Notably, the photocatalyzed difunctionalization of alkenes, as well as three- or four-component reactions, were studied, providing efficient access to an array of difluoroalkylated linear or cyclic products. Mechanistic studies have been conducted to provide a better understanding of the reaction mechanism for the synthesis of (phenylsulfonyl)-difluoromethylated alkenes. Exploring the reactivity of the (phenylsulfonyl)-difluoromethyl salt under photocatalysis has led to a straightforward, versatile strategyakin to a "Swiss army knife"for accessing a wide range of (phenylsulfonyl)-difluoromethyl-containing molecules.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.