Evidence map›Paper›PMID 40575233›Full record

ArticleCureus2025

Evaluation of the Protective Effects of Moringa oleifera, Zingiber officinale, and Allium sativum in a Rat Model of Chronic Kidney Disease (CKD).

Manjiri P Jalgaonkar, Rajeshwari K Bale, Alok D Singh, Gaurav M Doshi, Radhika K Raheja, Yogesh A Kulkarni, Manisha J Oza

Abstract read
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Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Manjiri P JalgaonkarQuality Assurance, Shri Vile Parle Kelavani Mandal's (SVKM) Dr. Bhanuben Nanavati College of Pharmacy, Mumbai, IND.
Rajeshwari K BalePharmacology, Shri Vile Parle Kelavani Mandal's (SVKM) Dr. Bhanuben Nanavati College of Pharmacy, Mumbai, IND.
Alok D SinghPharmacology, Shobhaben Pratapbhai Patel School of Pharmacy and Technology Management, Shri Vile Parle Kelavani Mandal's (SVKM) Narsee Monjee Institute of Management Studies (NMIMS) (Deemed to be University), Mumbai, IND.
Gaurav M DoshiPharmacology, Shri Vile Parle Kelavani Mandal's (SVKM) Dr. Bhanuben Nanavati College of Pharmacy, Mumbai, IND.
Radhika K RahejaQuality Assurance, Shri Vile Parle Kelavani Mandal's (SVKM) Dr. Bhanuben Nanavati College of Pharmacy, Mumbai, IND.
Yogesh A KulkarniPharmacology, Shobhaben Pratapbhai Patel School of Pharmacy and Technology Management, Shri Vile Parle Kelavani Mandal's (SVKM) Narsee Monjee Institute of Management Studies (NMIMS) (Deemed to be University), Mumbai, IND.
Manisha J OzaCardiovascular Research, Heart and Vascular Institute, Penn State College of Medicine, Penn State University, Hershey, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundOxidative stress plays a key role in the development and progression of chronic kidney disease (CKD). In this study, it has been hypothesized that the extract of

methodsRats were randomly divided into five groups: Group 1: normal control; Group 2: disease control; Group 3: CKD + polyherbal extract (250 mg/kg); Group 4: CKD + polyherbal extract (500 mg/kg); Group 5: CKD + polyherbal extract (1500 mg/kg). CKD was induced by feeding rats a 0.3% adenine-mixed diet for 28 days. Polyherbal extract was administered to rats, except for Groups 1 and 2, for 28 days.

resultsExperimental animals receiving treatment with polyherbal extract showed significant improvement in water intake (p< 0.001), urine volume (p< 0.01), urine creatinine (p < 0.05), plasma creatinine (p < 0.01), and blood urea nitrogen(p<0.05). Furthermore, the combined extract showed a potential effect in reducing oxidative stress and fibrosis, indicated by reduced hypertrophy in kidney tissue.

conclusionPolyherbal extract containing

Indexed as

adenineallium sativumchronic kidney diseasemoringa oleiferanatural productszingiber officinale

Identifiers

PMID40575233
PMCPMC12197805

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.