ArticleCureus2025
Sickle Cell Hepatopathy With Acute Hepatic Sequestration and Extreme Hyperbilirubinemia.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Hepatic Enzyme Abnormalities and Their Association With Hematological Parameters in Sickle Cell Disease: A Case-Control Study in Cameroon.Health science reports · 2026Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sickle cell disease (SCD) is a genetic disorder characterized by chronic hemolytic anemia and multi-organ dysfunction. The liver is frequently affected in SCD, with complications spanning from mild hyperbilirubinemia to acute liver failure. Acute hepatic sequestration (AHS), a rare but serious manifestation of sickle cell hepatopathy, can rapidly progress to multi-organ dysfunction syndrome (MODS). Cases with extreme hyperbilirubinemia (bilirubin > 20 mg/dL) remain exceptionally uncommon. A 19-year-old female patient with SCD presented with nausea, vomiting, generalized pain, dysuria, and suprapubic pain. On presentation, her vital signs were stable except for tachycardia (139 beats per minute (bpm)). Physical examination revealed scleral icterus, conjunctival pallor, and right upper quadrant (RUQ) tenderness. Initial laboratory results showed leukocytosis (white blood cell (WBC): 22.7 bil/L), hemoglobin (Hb) of 7.5 g/dL (baseline: 8.5 g/dL), and platelet (PLT) of 178 bil/L. Lactate dehydrogenase (LDH) was at 734 U/L. Liver function tests showed alkaline phosphatase (ALP) at 238 IU/L, aspartate transaminase (AST) at 52 U/L, alanine transaminase (ALT) at 49 U/L, and total bilirubin at 13.4 mg/dL. Abdominal ultrasound showed hepatomegaly (liver span of 19 cm) and gallstones without signs of cholecystitis. Blood cultures (2/2) tested positive for
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Registered trials
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