ArticleTurk gogus kalp damar cerrahisi dergisi2025
The importance of histology in patient selection for platinum-based neoadjuvant treatment in non-small cell lung cancer.
Article in Turk gogus kalp damar cerrahisi dergisi, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: This study aims to evaluate the prognostic factors for overall survival and progression-free survival in non-small cell lung cancer patients receiving platinum-based neoadjuvant therapy. Methods: Between January 2008 and December 2022, a total of 163 patients with clinical Stages 2B, 3A, and 3B non-small cell lung cancer (148 males, 15 females; mean age: 59.5±7.8 years; range, 33 to 76 years) who underwent operation after neoadjuvant chemotherapy or chemoradiotherapy were retrospectively analyzed. The prognostic factors for overall survival and progression-free survival were evaluated. Results: Higher major pathological response rate (p=0.021) and lower recurrence rate (p=0.009) were observed in patients with squamous cell carcinoma. The five-year progression-free survival rates were 56.9% and 34.1% for patients with squamous and non-squamous cell cancers (p=0.007) and the five-year overall survival rates were 68.2% and 52.2%, respectively (p=0.046). Squamous cell carcinoma histology was a favorable prognostic factor for both progression-free survival (p=0.008) and overall survival OS (p=0.031). Conclusion: Tumor histology may serve as a prognostic factor, helping to predict patient outcomes and guide the selection of neoadjuvant therapies before surgery. Currently, platinum-based chemotherapies are still used as a standard. Clinicians should consider tumor histology while deciding on neoadjuvant treatment.
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