ReviewAesthetic surgery journal. Open forum2025
The Role of Tranexamic Acid Use in Reduction Mammaplasty: A Systematic Review and Meta-Analysis.
Review in Aesthetic surgery journal. Open forum, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07131592 (The Effect of Tranexamic Acid on Drainage Volume and Time to Drain Removal in Reduction Mammaplasty Patients), which is not on this map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Effect of Tranexamic Acid on Drainage Volume and Time to Drain Removal in Reduction Mammaplasty Patients
Who cites it
3 citing papers in PubMed.
- Intravenous Tranexamic Acid Reduces Perioperative Blood Loss in Reduction Mammoplasty With Immediate Implant-Based Reconstruction: A Randomized, Triple-Blinded, Placebo-Controlled Trial.Aesthetic surgery journal · 2026Trial
- Effect of Tranexamic Acid to Reduce Postoperative Hematoma in Reduction Mammaplasty: A Retrospective Analysis of 656 Patients.Aesthetic plastic surgery · 2026Article
- International survey on the use of tranexamic acid in plastic surgery-Current practices and perspectives.JPRAS open · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Reduction mammoplasty (RM) decreases breast size but may lead to complications such as hematoma. Local tranexamic acid (TXA) is applied during surgery to minimize bleeding during or after the procedure. This systematic review, conducted in August 2024 using PubMed, Ovid Medline, and Ovid Embase, assessed the impact of local TXA on RM. The Methodological Index for Nonrandomized Studies and the Revised Cochrane risk of bias (RoB2) tools were employed to assess the risk of bias. Data analysis was performed using RevMan software. In this meta-analysis of 5 studies involving 608 patients (1216 breasts) undergoing RM, 46.8% of breasts were treated with TXA. Local TXA significantly reduced the 24-h drain output (mean difference -11.49, 95% CI, -15.71, -7.26;
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.