Evidence map›Paper›PMID 40574977›Full record

ArticleBrain communications2025

The potential dual role of tau phosphorylation: plasma phosphorylated-tau217 in newborns and Alzheimer's disease.

Fernando Gonzalez-Ortiz, Jakub Vávra, Emma Payne, Bjørn-Eivind Kirsebom, Ulrika Sjöbom, Cristiano Santos, Jordi Júlvez, Kaitlin Kramer, David Zalcberg, Laia Montoliu-Gaya and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Rethinking tau-targeted therapy in Alzheimer's disease: Toward a dual biomarker strategy.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Fernando Gonzalez-OrtizDepartment of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Gothenburg 417 11, Sweden.ORCID https://orcid.org/0000-0001-7897-9456
Jakub VávraDepartment of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Gothenburg 417 11, Sweden.
Emma PayneSt George Hospital, South Eastern Sydney Local Health District, Sydney, New South Wales 2217, Australia.
Bjørn-Eivind KirsebomDepartment of Neurology, University Hospital of North Norway, Tromsø 9038, Norway.ORCID https://orcid.org/0000-0002-1413-9578
Ulrika SjöbomLearning and Leadership for Health Care Professionals at the Institute of Health and Care Science at Sahlgrenska Academy at University of Gothenburg, Gothenburg 417 11, Sweden.ORCID https://orcid.org/0000-0003-4844-2396
Cristiano SantosClinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal 431 80, Sweden.
Jordi JúlvezClinical and Epidemiological Neuroscience Group (NeuroÈpia), Institut d'Investigació Sanitària Pere Virgili (IISPV), Reus 43204, Spain.
Kaitlin KramerCentral Clinical School, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales 2006, Australia.
David ZalcbergCentral Clinical School, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales 2006, Australia.
Laia Montoliu-GayaDepartment of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Gothenburg 417 11, Sweden.
Michael TurtonBioventix Plc, Farnham, Surrey GU9 7SX, UK.
Peter HarrisonBioventix Plc, Farnham, Surrey GU9 7SX, UK.
Ann HellströmDepartment of Clinical Neuroscience at the Institution of Neuroscience and Physiology at Sahlgrenska Academy at University of Gothenburg, Gothenburg 417 11, Sweden.ORCID https://orcid.org/0000-0002-9259-1244
Henrik ZetterbergDepartment of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Gothenburg 417 11, Sweden.ORCID https://orcid.org/0000-0003-3930-4354
Tormod FladbyDepartment of Neurology, Akershus University Hospital, Lørenskog 1478, Norway.
Marc Suárez-CalvetBarcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation, Barcelona 08005, Spain.
Robert D SandersCentral Clinical School, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales 2006, Australia.ORCID https://orcid.org/0000-0003-0113-0328
Kaj BlennowDepartment of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Gothenburg 417 11, Sweden.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tau phosphorylation plays an important role in brain physiology and pathology. During foetal development, it supports microtubule dynamics and neuroplasticity, whereas in Alzheimer's disease (AD), it drives pathological tau aggregation and tangle formation. In this multicentre study (

Indexed as

Alzheimer’s diseasenewbornsphosphorylated tauplasma biomarkers

Identifiers

PMID40574977
PMCPMC12198956

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.