Evidence map›Paper›PMID 40574972›Full record

ArticleBrain communications2025

The nonsteroidal anti-inflammatory drug meclofenamate mitigates kainic acid-induced seizures via TRPM4 inhibition.

Erzsébet Kövesdi, Laura Mundrucz, Attila Gyéresi, Máté Deák, Balázs Gaszner, Andy Pironet, Cecília Szekeres-Paraczky, Zsófia Maglóczky, Péter Gombás, Rudi Vennekens and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Astrocyte gap junctions and KFrontiers in cellular neuroscience · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Erzsébet KövesdiInstitute of Physiology, Medical School, University of Pécs, Pécs H-7624, Hungary.
Laura MundruczInstitute of Physiology, Medical School, University of Pécs, Pécs H-7624, Hungary.
Attila GyéresiInstitute of Physiology, Medical School, University of Pécs, Pécs H-7624, Hungary.
Máté DeákInstitute of Physiology, Medical School, University of Pécs, Pécs H-7624, Hungary.
Balázs GasznerDepartment of Anatomy, Medical School and Research Group for Mood Disorders, Centre for Neuroscience, University of Pécs, Pécs H-7624, Hungary.ORCID https://orcid.org/0000-0003-2830-2732
Andy PironetLaboratory of Ion Channel Research, Biomedical Sciences Group, Department of Cellular and Molecular Medicine, VIB-KU Leuven Center for Brain & Disease Research, KU Leuven, Leuven 3000, Belgium.ORCID https://orcid.org/0000-0003-2869-1096
Cecília Szekeres-ParaczkyHuman Brain Research Laboratory, HUN-REN Institute of Experimental Medicine, Budapest H-1083, Hungary.
Zsófia MaglóczkyHuman Brain Research Laboratory, HUN-REN Institute of Experimental Medicine, Budapest H-1083, Hungary.
Péter GombásDepartment of Pathology, St. Borbála Hospital, Tatabánya H-2800, Hungary.
Rudi VennekensLaboratory of Ion Channel Research, Biomedical Sciences Group, Department of Cellular and Molecular Medicine, VIB-KU Leuven Center for Brain & Disease Research, KU Leuven, Leuven 3000, Belgium.
Viktória KormosDepartment of Pharmacology and Pharmacotherapy, Centre for Neuroscience, Medical School, University of Pécs, Pécs H-7624, Hungary.
Miklós KecskésInstitute of Physiology, Medical School, University of Pécs, Pécs H-7624, Hungary.ORCID https://orcid.org/0000-0002-0240-0476

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Transient receptor potential melastatin 4 (TRPM4) is a Ca

Indexed as

hippocampusmeclofenamatemossy cellseizureTRPM4

Identifiers

PMID40574972
PMCPMC12199760

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.