ArticleFrontiers in pediatrics2025
Neonatal herpes simplex virus infection combined with neonatal lupus erythematosus: a case reported.
Article in Frontiers in pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Neonatal herpes simplex virus (HSV) infection complicated by neonatal lupus erythematosus (NLE) is rare and is associated with high mortality and poor neurological outcomes in survivors. Enhancing clinical understanding of this condition is essential to reduce misdiagnosis and missed diagnosis. Case presentation: A neonate presented with complete atrioventricular block (CAVB) as the initial clinical manifestation, which was successfully resolved following combined therapy with isoproterenol, hydrocortisone, and intravenous immunoglobulin (IVIG). Maternal history of HSV infection during pregnancy, coupled with suspected herpetic skin lesions in the neonate, strongly suggested HSV as the putative etiology. Despite initiation of acyclovir therapy for confirmed HSV infection, the recurrence of cutaneous rash prompted further evaluation, leading to the diagnosis of NLE. Notably, no specific treatment was administered for NLE, as the condition remained clinically quiescent. Follow-up at 7 months of age revealed no neurological abnormalities, no recurrence of CAVB, and gradual resolution of the rash. Conclusion: The clinical presentations of neonatal HSV infection and NLE can overlap. Early diagnosis and intervention are crucial for successful treatment and improved prognosis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.