ArticleFrontiers in immunology2025
Immune monitoring and risk of infection in pediatric liver transplantation: a prospective study.
Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
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Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Etiology and management of cholangitis in pediatric liver transplant recipients: a systematic review.Current opinion in organ transplantation · 2026Pooled it
- An Approach to Antibody-Mediated Rejection in Pediatric Liver Transplantation.Pediatric transplantation · 2026Review
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Authors and funding
11 authors.
Funding
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Abstract
Background: Immune monitoring has been proposed to optimize immunosuppressive therapy in liver recipients. This study aims to describe immunological changes following liver transplantation in pediatric recipients and to identify immune markers associated with post-transplant complications. Methods: The immunological status of 95 pediatric liver recipients was prospectively assessed before transplantation and at 1, 3, 6, 9 and 12 months post-transplantation. Serum immunoglobulins (Ig) were measured by nephelometry and immunophenotype was evaluated by flow cytometry. T, B and NK lymphocyte counts were adjusted for age using standard reference ranges. Results: Graft rejection, post-transplant lymphoproliferative disorder and autoimmune hepatitis was diagnosed in 6%, 2% and 0% patients, respectively. Early infections affected 43% patients, while late infections occurred in 17%, 24%, 10% and 9% recipients at each follow-up interval. Baseline immune dysregulation primarily involved the cellular compartment, with 78% recipients showing lymphopenia. Lymphocyte subpopulation scores improved following liver transplantation, with CD4 Conclusions: Baseline immune dysregulation resolved within the first months post-transplantation. Early infections were unrelated to immune markers, while late infections were associated with CD3
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