ArticleFrontiers in cardiovascular medicine2025
Quantitative comparisons of pulmonary artery hemodynamics before and after Pulsta valve implantation in patients with Tetralogy of Fallot using computational fluid dynamics.
Article in Frontiers in cardiovascular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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6 authors.
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Abstract
Background and objectives: The evaluation of percutaneous pulmonary valve implantation (PPVI) performance has been predominantly confined to assessing changes in the right ventricular volume using magnetic resonance imaging (MRI). This study aimed to evaluate the hemodynamic changes in the pulmonary arteries following PPVI using computational fluid dynamics (CFD) in patients with Tetralogy of Fallot. Methods: We conducted CFD analysis based on MRI scans performed before and after PPVI using Pulsta valve in nine patients who underwent PPVI between 2016 and 2021. Statistical analysis, including Wilcoxon rank-sum tests and multivariable linear regression, was performed to examine the associations between CFD data and non-CFD factors, as well as changes in these parameters after PPVI. Results: Before PPVI, forward and backward flow velocities in the right pulmonary artery (RPA) were higher than those in the left pulmonary artery (LPA) and main pulmonary artery (MPA) (forward: MPA/RPA/LPA = 19.9/32.7/19.3 cm/s, backward: MPA/RPA/LPA = 10.1/17.0/9.1 cm/s). After PPVI, velocities decreased (forward: MPA/RPA/LPA = 13.3/14.2/8.3 cm/s, backward: MPA/RPA/LPA = 2.3/2.6/1.7 cm/s), reducing the differences among PAs. After PPVI, the vorticity (RPA; 3.9-1.6/s, Conclusion: A deeper understanding of the hemodynamics of pulmonary arteries using CFD can aid in evaluating the effectiveness of PPVI and refining its indications in patients with Tetralogy of Fallot.
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