ArticleFrontiers in cardiovascular medicine2025
Shexiang Tongxin Dripping Pills regulates SOD/TNF-α/IL-6 pathway to inhibit inflammation and oxidative stress to improve myocardial ischemia-reperfusion injury in mice.
Article in Frontiers in cardiovascular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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- Endothelial Activation and Stress Index (EASIX) as a novel index associated with no-reflow phenomenon in STEMI: a bi-center retrospective study.BMC cardiovascular disorders · 2026Article
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Abstract
Introduction: Shexiang Tongxin Dropping Pills (STDP), a traditional Chinese medicine (TCM), is clinically used for cardiovascular diseases like myocardial ischemia. Myocardial ischemia-reperfusion injury (MIRI), worsened by oxidative stress and inflammation, remains a significant problem, and the mechanisms underlying STDP's cardioprotection are incompletely understood. This study aimed to investigate STDP's effects on the SOD/TNF-α/IL-6 pathway and its impact on inflammation and oxidative stress in MIRI. Methods: A mouse model of MIRI was employed to evaluate the cardioprotective effects and mechanisms of STDP Results: STDP pretreatment significantly enhanced serum SOD activity and reduced cardiac ROS levels and cardiomyocyte apoptosis. It effectively downregulated mRNA and protein expression of IL-1β, TNF-α, and IL-6. Histopathology revealed reduced inflammatory cell infiltration and more intact cardiomyocyte morphology in STDP-treated groups. TTC staining confirmed a reduction in myocardial infarction size. Cardiac function assessments showed STDP improved both contractility and diastolic function post-MIRI and reduced arrhythmia incidence. Discussion: STDP ameliorates MIRI in mice by inhibiting inflammatory responses and oxidative stress, primarily through modulation of the SOD/TNF-α/IL-6 pathway. Its cardioprotective effects include reducing apoptosis, inflammation, ROS, infarction size, and arrhythmias, while improving cardiac function and tissue repair. These findings elucidate a key mechanism for STDP and provide empirical support for its clinical use in MIRI, offering innovative perspectives for managing cardiovascular disorders with TCM and facilitating the integration of traditional and modern medicine.
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