Evidence map›Paper›PMID 40574807›Full record

ArticleEuropean heart journal open2025

Exercise capacity in heart failure: a systematic review and meta-analysis of HFrEF and HFpEF disparities in VO

Konstantinos Prokopidis, Krzysztof Irlik, Theocharis Ispoglou, Panagiotis Ferentinos, Alexandros Mitropoulos, Mathias Schlögl, Masoud Isanejad, Kamil Kegler, Katarzyna Nabrdalik, Gregory Y H Lip

Abstract read
In one paragraph

Article in European heart journal open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Konstantinos ProkopidisDepartment of Musculoskeletal Ageing and Science, Institute of Life Course and Medical Sciences, University of Liverpool, 6 West Derby St, Liverpool L7 8TX, UK.ORCID https://orcid.org/0000-0002-6264-9388
Krzysztof IrlikStudents' Scientific Association by the Department of Internal Medicine, Diabetology and Nephrology in Zabrze, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, Katowice, Poland.ORCID https://orcid.org/0000-0001-9699-1686
Theocharis IspoglouCarnegie School of Sport, Leeds Beckett University, Leeds LS1 3HE, UK.
Panagiotis FerentinosCarnegie School of Sport, Leeds Beckett University, Leeds LS1 3HE, UK.
Alexandros MitropoulosDepartment of Nursing and Midwifery, Sheffield Hallam University, Howard St, Sheffield City Centre, Sheffield S1 1WB, UK.
Mathias SchlöglUniversity Clinic for Acute Geriatric Care, City Hospital Waid Zurich, Tièchestrasse 99, 8037 Zürich, Switzerland.ORCID https://orcid.org/0000-0002-6299-8852
Masoud IsanejadDepartment of Musculoskeletal Ageing and Science, Institute of Life Course and Medical Sciences, University of Liverpool, 6 West Derby St, Liverpool L7 8TX, UK.
Kamil KeglerStudents' Scientific Association by the Department of Internal Medicine, Diabetology and Nephrology in Zabrze, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, Katowice, Poland.
Katarzyna NabrdalikLiverpool Centre for Cardiovascular Science at University of Liverpool, Liverpool John Moores University and Liverpool Heart & Chest Hospital, Thomas Dr, Liverpool L14 3PE, UK.
Gregory Y H LipLiverpool Centre for Cardiovascular Science at University of Liverpool, Liverpool John Moores University and Liverpool Heart & Chest Hospital, Thomas Dr, Liverpool L14 3PE, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aims: Heart failure (HF) with reduced ejection fraction (HFrEF) and HF with preserved ejection fraction (HFpEF) exhibit unique physiological pathways, influencing exercise capacity and functional performance. This systematic review and meta-analysis aimed to compare peak oxygen consumption (VO Methods and results: A systematic literature search of cohort studies via databases (PubMed, Web of Science, Scopus, and Cochrane Library) was conducted from inception until October 2024. A meta-analysis using a random-effects model to calculate the pooled effects was employed. Forty-six studies were included. HFrEF patients demonstrated significantly greater 6MWD compared to HFpEF ( Conclusion: HFpEF patients demonstrated superior VO

Indexed as

Heart failureHFpEFHFrEFPhysical functionVO2peak

Identifiers

PMID40574807
PMCPMC12202100

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.