Evidence map›Paper›PMID 40574656›Full record

ArticleBioinformatics (Oxford, England)2025

NetMedPy: a Python package for large-scale network medicine screening.

Andres Aldana, Michael Sebek, Gordana Ispirova, Rodrigo Dorantes-Gilardi, Joseph Loscalzo, Albert-László Barabási, Giulia Menichetti

Abstract read
In one paragraph

Article in Bioinformatics (Oxford, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Chemical Complexity of Food and Implications for Therapeutics.The New England journal of medicine · 2025
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Andres AldanaNetwork Science Institute, Northeastern University, 177 Huntington Avenue, Boston, MA 02115, USA.
Michael SebekNetwork Science Institute, Northeastern University, 177 Huntington Avenue, Boston, MA 02115, USA.ORCID 0000-0003-3347-7131
Gordana IspirovaChanning Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA.
Rodrigo Dorantes-GilardiNetwork Science Institute, Northeastern University, 177 Huntington Avenue, Boston, MA 02115, USA.
Joseph LoscalzoDivision of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA.
Albert-László BarabásiNetwork Science Institute, Northeastern University, 177 Huntington Avenue, Boston, MA 02115, USA.
Giulia MenichettiNetwork Science Institute, Northeastern University, 177 Huntington Avenue, Boston, MA 02115, USA.ORCID 0000-0001-5201-6774

Funding

Methods for Unraveling the Impact of Dietary Xenobiotics on COPD Exacerbations with Multi-Dimensional NetworksK25HL173665 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI Giulia Menichetti · 2024 to 2026
$487k
American Heart Association 24MERIT1185447National Institutes of Health/National Heart, Lung, and Blood Institute K25HL173665NHLBI NIH HHS K25 HL173665
6 · The paper itself

Abstract

summaryNetwork medicine leverages the quantification of information flow within sub-cellular networks to elucidate disease etiology and comorbidity, as well as to predict drug efficacy and identify potential therapeutic targets. However, current Network Medicine toolsets often lack computationally efficient data processing pipelines that support diverse scoring functions, network distance metrics, and null models. These limitations hamper their application in large-scale molecular screening, hypothesis testing, and ensemble modeling. To address these challenges, we introduce NetMedPy, a highly efficient and versatile computational package designed for comprehensive Network Medicine analyses. AVAILABILITY AND IMPLEMENTATION: NetMedPy is an open-source Python package under an MIT license. Source code, documentation, and installation instructions can be downloaded from https://github.com/menicgiulia/NetMedPy and https://pypi.org/project/NetMedPy. The package can run on any standard desktop computer or computing cluster.

Indexed as

Computational BiologySoftwareHumans

Identifiers

PMID40574656
PMCPMC12401583

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.