Evidence map›Paper›PMID 40574540›Full record

Trial reportEuropean psychiatry : the journal of the Association of European Psychiatrists2025

Clinical effects and correlates of standard rTMS and theta burst stimulation (TBS) on suicidal ideation in late-life depression.

Hyewon H Lee, Katharina Göke, Rafae A Wathra, Benoit Mulsant, Alisson P Trevizol, Jonathan Downar, Shawn M McClintock, Sean M Nestor, Yoshihiro Noda, Tarek K Rajji and 2 more

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in European psychiatry : the journal of the Association of European Psychiatrists, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02998580 (Conventional Bilateral rTMS vs. Bilateral Theta Burst Stimulation for Late-Life Depression), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02998580 nacompletednot on this map

Conventional Bilateral rTMS vs. Bilateral Theta Burst Stimulation for Late-Life Depression

TypeinterventionalSponsorCentre for Addiction and Mental HealthRan2016 to 2020Enrolled163ConditionsMajor DepressionArmsLFR followed by HFL, cTBS followed by iTBS
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Hyewon H LeeTemerty for Therapeutic Brain Intervention and Campbell Family Research Institute, https://ror.org/03e71c577Centre for Addiction and Mental Health, Toronto, ON, Canada.ORCID 0000-0001-5032-0350
Katharina GökeTemerty for Therapeutic Brain Intervention and Campbell Family Research Institute, https://ror.org/03e71c577Centre for Addiction and Mental Health, Toronto, ON, Canada.ORCID 0000-0003-4365-0268
Rafae A WathraDepartment of Psychiatry, Temerty Faculty of Medicine, https://ror.org/03dbr7087University of Toronto, Toronto, ON, Canada.
Benoit MulsantTemerty for Therapeutic Brain Intervention and Campbell Family Research Institute, https://ror.org/03e71c577Centre for Addiction and Mental Health, Toronto, ON, Canada.ORCID 0000-0002-0303-6450
Alisson P TrevizolTemerty for Therapeutic Brain Intervention and Campbell Family Research Institute, https://ror.org/03e71c577Centre for Addiction and Mental Health, Toronto, ON, Canada.
Jonathan DownarTemerty for Therapeutic Brain Intervention and Campbell Family Research Institute, https://ror.org/03e71c577Centre for Addiction and Mental Health, Toronto, ON, Canada.
Shawn M McClintockDepartment of Psychiatry, https://ror.org/05byvp690University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID 0000-0001-5372-0261
Sean M NestorDepartment of Psychiatry, Temerty Faculty of Medicine, https://ror.org/03dbr7087University of Toronto, Toronto, ON, Canada.ORCID 0000-0002-8848-5027
Yoshihiro NodaDepartment of Neuropsychiatry, Faculty of Medicine, https://ror.org/01k8ej563Keio University School of Medicine, Tokyo, Japan.ORCID 0000-0002-2155-0357
Tarek K RajjiDepartment of Psychiatry, https://ror.org/05byvp690University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID 0000-0002-8324-2560
Zafiris J DaskalakisDepartment of Psychiatry, https://ror.org/0168r3w48University of California, San Diego Health, San Diego, CA, USA.
Daniel M BlumbergerTemerty for Therapeutic Brain Intervention and Campbell Family Research Institute, https://ror.org/03e71c577Centre for Addiction and Mental Health, Toronto, ON, Canada.ORCID 0000-0002-8422-5818

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPrevious studies have shown that repetitive transcranial magnetic stimulation (rTMS) can treat suicidal symptoms; however, the effects of rTMS on suicidal ideation (SI) in late-life depression (LLD) have not been well-characterized, particularly with theta burst stimulation (TBS).

methodsData were analyzed from 84 older adults with depression from the FOUR-D trial (ClinicalTrials.gov identifier: NCT02998580), who received either bilateral standard rTMS or bilateral TBS targeting the dorsolateral prefrontal cortex. The primary outcome was change in the Beck Scale for Suicide Ideation (SSI). The secondary outcome was remission of SI. Demographic, cognitive, and clinical characteristics that may moderate the effects of rTMS or TBS on SI were explored.

resultsThere was a statistically significant change in the total SSI score over time [

conclusionsBoth bilateral rTMS and bilateral TBS were effective in reducing SI in LLD. There may be sex differences in response to TBS, with females having more favorable response in reducing SI. There may be an association between improvement in cognitive flexibility and inhibition and reduction of SI.

Indexed as

Dorsolateral Prefrontal CortexMajor Depressive DisorderOutcome Assessment, Health CareSuicidal IdeationTranscranial Magnetic StimulationAgedFemaleHumansMaleMiddle AgedTheta Rhythmdepressionlate liferTMSsuicidal ideationtheta burst stimulation

Identifiers

PMID40574540
PMCPMC12260718

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.