Evidence map›Paper›PMID 40574460›Full record

ArticleGut microbes2025

Gut bacteriophages induce specific-reprogramming of macrophages to generate a protective innate immunity response to lipopolysaccharide exposure.

Xiang Hou, Huiyan Ding, Heye Wang, Jing Wang, Hui Liu, Hao Hu, Craig Billington, Ran Wang, Lili Zhang

Abstract read
In one paragraph

Article in Gut microbes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Xiang HouInstitute of Food Safety and Nutrition, Jiangsu Academy of Agricultural Sciences, Nanjing, Jiangsu, China.
Huiyan DingDepartment of Interventional Radiology, Zhejiang Cancer Hospital, Hangzhou, Zhejiang, China.
Heye WangInstitute of Food Safety and Nutrition, Jiangsu Academy of Agricultural Sciences, Nanjing, Jiangsu, China.
Jing WangInstitute of Food Safety and Nutrition, Jiangsu Academy of Agricultural Sciences, Nanjing, Jiangsu, China.
Hui LiuInstitute of Food Safety and Nutrition, Jiangsu Academy of Agricultural Sciences, Nanjing, Jiangsu, China.
Hao HuInstitute of Food Safety and Nutrition, Jiangsu Academy of Agricultural Sciences, Nanjing, Jiangsu, China.
Craig BillingtonInstitute of Environmental Science and Research, Christchurch, New Zealand.
Ran WangMinistry of Agriculture, Key Lab of Food Quality and Safety of Jiangsu Province-State Key Laboratory Breeding Base, Risk Assessment Laboratory of Agro-Products Processing Quality and Safety (Nanjing), Nanjing, Jiangsu, China.
Lili ZhangInstitute of Food Safety and Nutrition, Jiangsu Academy of Agricultural Sciences, Nanjing, Jiangsu, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Macrophages play essential roles in generating a tolerogenic resident environment, but the interactions between bacteriophages and their action in macrophage tolerance memory remain unknown. Here, we find that gut bacteriophage exposure

Indexed as

BacteriophagesGastrointestinal MicrobiomeImmunity, InnateLipopolysaccharidesMacrophagesAnimalsCytokinesImmune ToleranceInterleukin-10MiceMice, Inbred C57BLCytokinesInterleukin-10LipopolysaccharidesBacteriophageepigenetic mechanismsIL-10innate immune memorymacrophage

Identifiers

PMID40574460
PMCPMC12218588

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.