Evidence map›Paper›PMID 40574410›Full record

ArticleChannels (Austin, Tex.)2025

Astrocytic abnormalities in brain-specific

Yeojung Koh, Maria Noterman-Soulinthavong, Anusha Bangalore, Uapingena P Kandjoze, Zea Bud, Kamryn L Noel, Hami Lee, Kathryn Franke, Coral J Cintrón-Pérez, Anjali M Rajadhyaksha and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Channels (Austin, Tex.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Yeojung KohDepartment of Psychiatry, Case Western Reserve University, Cleveland, OH, USA.
Maria Noterman-SoulinthavongDepartement of Psychiatry, University Iowa Carver College of Medicine, Iowa City, IA, USA.
Anusha BangaloreDepartment of Neurosciences, Case Western Reserve University, Cleveland, OH, USA.
Uapingena P KandjozeDepartment of Psychology, Earlham College, Richmond, IN, USA.
Zea BudDepartment of Psychiatry, Case Western Reserve University, Cleveland, OH, USA.
Kamryn L NoelDepartment of Psychiatry, Case Western Reserve University, Cleveland, OH, USA.
Hami LeeCenter for Substance Abuse Research and Department of Neural Sciences, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, USA.
Kathryn FrankeDepartment of Psychiatry, Case Western Reserve University, Cleveland, OH, USA.
Coral J Cintrón-PérezDepartment of Psychiatry, Case Western Reserve University, Cleveland, OH, USA.
Anjali M RajadhyakshaCenter for Substance Abuse Research and Department of Neural Sciences, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, USA.
Eric B TaylorPappajohn Biomedical Institute, University of Iowa, Iowa City, IA, USA.
Andrew A PieperDepartment of Psychiatry, Case Western Reserve University, Cleveland, OH, USA.ORCID 0000-0001-6299-6577

Funding

Endophenotype Network-based Approaches to Prediction and Population-based Validation of In Silico Drug Repurposing for Alzheimer's DiseaseR01AG066707 · NIA · CLEVELAND CLINIC LERNER COM-CWRU · PI Feixiong Cheng · 2020 to 2026
$4.9M
Alzheimer's MultiOme Data Repurposing: Artificial Intelligence, Network Medicine, and Therapeutics DiscoveryU01AG073323 · NIA · CLEVELAND CLINIC LERNER COM-CWRU · PI BEKRIS, LYNN, CHENG, FEIXIONG · 2021 to 2025
$4.0M
Circuit and Synaptic Mechanisms of Endocannabinoid-Opioid CrosstalkR01DA054368 · NIDA · WEILL MEDICAL COLL OF CORNELL UNIV · PI Francis Sang Yong Lee, Anjali M Rajadhyaksha · 2022 to 2026
$3.5M
Neuroprotective actions of cystathionine g-lyase through gasotransmitter hydrogen sulfide signalingR01AG071512 · NIA · JOHNS HOPKINS UNIVERSITY · PI Bindu Paul · 2022 to 2026
$3.4M
Regulation of Hepatic Macronutrient Metabolism by Mitochondrial Citrate TransportR01DK104998 · NIDDK · UNIVERSITY OF IOWA · PI TAYLOR, ERIC B · 2015 to 2022
$3.2M
Investigating the mechanistic contribution of Cav1.2 channels in extinction of cocaine-associated memoriesR01DA053261 · NIDA · WEILL MEDICAL COLL OF CORNELL UNIV · PI Anjali M Rajadhyaksha · 2022 to 2026
$2.6M
GABAergic Interneuron Dysfunction in Developing Cortical Circuits Underlying Autism Spectrum DisordersR01MH125006 · NIMH · WEILL MEDICAL COLL OF CORNELL UNIV · PI DE MARCO GARCIA, NATALIA VANESA, RAJADHYAKSHA, ANJALI M · 2021 to 2025
$2.1M
L-Type Calcium Channel Mechanisms Mediating Comorbid Substance Use and Mood DisordersR01DA050454 · NIDA · YALE UNIVERSITY · PI ADDY, NII A · 2020 to 2024
$2.0M
Mechanisms of blood-brain barrier deterioration in vascular cognitive impairment and Alzheimers diseaseF99AG083111 · NIA · CASE WESTERN RESERVE UNIVERSITY · PI KOH, YEO JUNG · 2023 to 2024
$98k
BLRD VA I01 BX005976NIA NIH HHS F99 AG083111NIA NIH HHS R01 AG066707NIA NIH HHS R01 AG071512NIA NIH HHS U01 AG073323NIDA NIH HHS R01 DA050454NIDA NIH HHS R01 DA053261NIDA NIH HHS R01 DA054368NIDDK NIH HHS R01 DK104998NIMH NIH HHS R01 MH125006
6 · The paper itself

Abstract

Intronic genetic variants within the

Indexed as

AstrocytesBlood-Brain BarrierBrainCalcium Channels, L-TypeMental DisordersAnimalsMiceMice, KnockoutMutationCACNA1C protein, mouseCalcium Channels, L-TypeAQP4aquaporin 4CACNA1CCalciumCav1.2neuropsychiatric disease

Identifiers

PMID40574410
PMCPMC12218471

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.