Evidence map›Paper›PMID 40574369›Full record

ArticleESC heart failure2025

Heart transplantation outcomes with donation after circulatory death in patients with left ventricular assist device.

Aris Karatasakis, Edwin Grajeda Silvestri, Gatha G Nair, Benjamin Zuniga, Song Li, Claudius Mahr, Richard K Cheng, April S Stempien-Otero, Ioannis Dimarakis, Maziar Khorsandi and 4 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in ESC heart failure, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Aris KaratasakisDivision of Cardiology, University of Washington Medical Center, Seattle, Washington, USA.
Edwin Grajeda SilvestriPresbyterian Heart & Vascular Care, Albuquerque, New Mexico, USA.
Gatha G NairDivision of Cardiology, Rush University Medical Center, Chicago, Illinois, USA.
Benjamin ZunigaDepartment of Internal Medicine, University of Connecticut, Farmington, Connecticut, USA.
Song LiInstitute for Advanced Cardiac Care, Medical City Healthcare, Dallas, Texas, USA.
Claudius MahrInstitute for Advanced Cardiac Care, Medical City Healthcare, Dallas, Texas, USA.
Richard K ChengDivision of Cardiology, University of Washington Medical Center, Seattle, Washington, USA.
April S Stempien-OteroDivision of Cardiology, University of Washington Medical Center, Seattle, Washington, USA.
Ioannis DimarakisDivision of Cardiothoracic Surgery, University of Washington Medical Center, Seattle, Washington, USA.
Maziar KhorsandiDivision of Cardiothoracic Surgery, University of Washington Medical Center, Seattle, Washington, USA.
Jay D PalDivision of Cardiothoracic Surgery, University of Washington Medical Center, Seattle, Washington, USA.
Jorge R KizerCardiology Section, San Francisco VA Health Care System, San Francisco, California, USA.
Marc A SimonDivision of Cardiology, University of California San Francisco, San Francisco, California, USA.
Claudio A BravoInstitute for Advanced Cardiac Care, Medical City Healthcare, Dallas, Texas, USA.ORCID https://orcid.org/0000-0002-7561-052X

Funding

HCA Healthcare
6 · The paper itself

Abstract

aimsDonation after circulatory death (DCD) has emerged as a strategy to increase the donor pool for heart transplantation (HT). Left ventricular assist device (LVAD) patients represent a discrete and unique population. We sought to explore the early outcomes of DCD-HT compared with donation after brain death (DBD) HT in LVAD patients. METHODS AND

resultsWe obtained data from the United Network of Organ Sharing database. The main cohort consisted of adults listed for HT between 17 October 2018 and 3 July 2024, with LVAD implanted before or after listing. The primary outcome was survival within the first year post-HT. There were 3336 patients with LVAD underwent HT during the study period (median age 55 years (interquartile range 45-62), 24% women, 29% Black, 89% DBD). The short-term post-HT mortality in LVAD patients who underwent DCD HT was not significantly different from DBD (adjusted hazard ratio [aHR] 1.00, 95% CI 0.70-1.42, P value > 0.9). The likelihood of transplantation within 1 year was higher at centres performing DCD (aHR 1.44, 95% CI 1.39-1.49, P < 0.001). Despite the longer donor-recipient distance in DCD-HT, in-hospital outcomes (stroke and acute kidney injury requiring dialysis) were not different from DBD-HT. A higher incidence of primary graft dysfunction (adjusted risk ratio [aRR] 3.8, 95% CI 2.5-5.7, P < 0.001), and treated rejection was observed with DCD-HT (aRR 1.48, 95% CI 1.14-1.93, P = 0.003).

conclusionsIn LVAD patients who received DCD HT, early post-transplant survival, stroke, acute kidney injury and length of stay were not significantly different from those who underwent DBD HT. There were increased rates of primary graft dysfunction and treated rejection among LVAD patients who underwent DCD HT. Patients in a DCD centre were significantly more likely to be transplanted earlier.

Indexed as

Heart-Assist DevicesHeart FailureHeart TransplantationTissue and Organ ProcurementTissue DonorsAdultFemaleFollow-Up StudiesHumansMaleMiddle AgedRetrospective StudiesSurvival RateUnited StatesDonation after brain deathDonation after circulatory deathHeart transplantationLeft ventricular assist device

Identifiers

PMID40574369
PMCPMC12450753

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.