Evidence map›Paper›PMID 40574360›Full record

Observational studyCurrent Alzheimer research2025

Serum Biomarkers of Vascular Dysfunction, Neuropsychiatric Symptoms, and Clinical Severity of Alzheimer's Disease: A Cross-sectional Study.

Antonina Luca, Antonis Politis, Maria Luca, Raffaele Ferri, Margherita Grasso, Filippo Drago, Alessandra Nicoletti, Alessandro Serretti

Abstract readObservational Study
PubMed Publisher
In one paragraph

Observational study in Current Alzheimer research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Antonina LucaDepartment of Medicine and Surgery, Kore University of Enna, Enna, Italy.
Antonis PolitisFirst Department of Psychiatry, Eginition Hospital, National & Kapodistrian University of Athens, Athens, Greece.
Maria LucaCentre for Addiction, Adrano-Bronte, Italy.
Raffaele FerriDepartment of Sleep Medicine, Oasi Research Institute-IRCCS, Troina, Italy.
Margherita GrassoDepartment of Sleep Medicine, Oasi Research Institute-IRCCS, Troina, Italy.
Filippo DragoDepartment of Biomedical and Biotechnological Sciences, Section of Pharmacology, University of Catania, Catania, Italy.
Alessandra NicolettiDepartment of Medical, Surgical Sciences and Advanced Technologies "GF Ingrassia"; University of Catania, Catania, Italy.
Alessandro SerrettiDepartment of Medicine and Surgery, Kore University of Enna, Enna, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe aim of this study was to assess the relationship between serum biomarkers of vascular dysfunction and neuropsychological performance in Alzheimer's disease (AD) patients. MATERIALS AND

methodsIn this cross-sectional observational study, outpatients with AD who were referred to the Neuropsychiatry Clinic of the Eginition Hospital in Athens from January 2006 to December 2006 were consecutively enrolled. All the participants underwent a neuropsychological assessment. The serum concentrations of Apolipoprotein A1 (ApoA1), Vascular Cell Adhesion Molecule 1 (VCAM- 1), Intercellular Adhesion Molecule 1 (ICAM-1), Lipoprotein-A (LpA), and C-Reactive Protein (CR-P) were determined.

resultsFifty-six AD patients were enrolled. ApoA1 was correlated with Mini Mental State Examination (MMSE) and AD Cooperative Study-Activities of Daily Living (ADCS-ADL). Combined biomarkers were correlated with MMSE, Neuropsychiatry Inventory, Clinical Dementia Rating Scale, and ADCS-ADL. DISCUSSION: Our study highlights the association between serum biomarkers of vascular dysfunction- specifically ApoA1, VCAM-1, ICAM-1, LpA, and CRP-and the cognitive and behavioral features of Alzheimer's Disease.

conclusionThese findings suggest that assessing vascular biomarkers may offer valuable insights into the pathophysiological mechanisms underlying cognitive and behavioral decline in AD.

Indexed as

Alzheimer DiseaseActivities of Daily LivingAgedAged, 80 and overApolipoprotein A-IBiomarkersC-Reactive ProteinCross-Sectional StudiesFemaleHumansIntercellular Adhesion Molecule-1MaleMental Status and Dementia TestsMiddle AgedNeuropsychological TestsSeverity of Illness IndexApolipoprotein A-IBiomarkersC-Reactive ProteinIntercellular Adhesion Molecule-1Vascular Cell Adhesion Molecule-1Alzheimer’s diseasebehavioral decline.biomarkersneuropsychological performancesserumvascular dysfunction

Identifiers

PMID40574360

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.