Evidence map›Paper›PMID 40574333›Full record

ArticlePlant communications2025

POLARIS is a copper-binding peptide that interacts with ETR1 to negatively regulate ethylene signaling in Arabidopsis.

Anna J Mudge, Saher Mehdi, Will Michaels, Beatriz Orosa-Puente, Weiran Shen, Charlie Tomlinson, Wenbin Wei, Claudia Hoppen, Buket Uzun, Dipan Roy and 6 more

Abstract read
In one paragraph

Article in Plant communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
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  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Anna J MudgeDepartment of Biosciences, Durham University, Durham DH1 3LE, UK.
Saher MehdiDepartment of Biosciences, Durham University, Durham DH1 3LE, UK.
Will MichaelsDepartment of Biosciences, Durham University, Durham DH1 3LE, UK; Department of Chemistry, Durham University, Durham DH1 3LE, UK.
Beatriz Orosa-PuenteDepartment of Biosciences, Durham University, Durham DH1 3LE, UK.
Weiran ShenDepartment of Biosciences, Durham University, Durham DH1 3LE, UK.
Charlie TomlinsonDepartment of Chemistry, Durham University, Durham DH1 3LE, UK.
Wenbin WeiDepartment of Biosciences, Durham University, Durham DH1 3LE, UK.
Claudia HoppenInstitute of Biochemical Plant Physiology, Heinrich Heine University Düsseldorf, 40204 Düsseldorf, Germany.
Buket UzunInstitute of Biochemical Plant Physiology, Heinrich Heine University Düsseldorf, 40204 Düsseldorf, Germany.
Dipan RoyDepartment of Biosciences, Durham University, Durham DH1 3LE, UK.
Flora M HetheringtonDepartment of Biosciences, Durham University, Durham DH1 3LE, UK.
Jennifer F ToppingDepartment of Biosciences, Durham University, Durham DH1 3LE, UK.
Ari SadanandomDepartment of Biosciences, Durham University, Durham DH1 3LE, UK.
Georg GrothInstitute of Biochemical Plant Physiology, Heinrich Heine University Düsseldorf, 40204 Düsseldorf, Germany.
Nigel J RobinsonDepartment of Biosciences, Durham University, Durham DH1 3LE, UK; Department of Chemistry, Durham University, Durham DH1 3LE, UK. Electronic address: nigel.robinson@durham.ac.uk.
Keith LindseyDepartment of Biosciences, Durham University, Durham DH1 3LE, UK. Electronic address: keith.lindsey@durham.ac.uk.

Funding

Biotechnology and Biological Sciences Research Council BB/E006531/1Biotechnology and Biological Sciences Research Council BB/J014516/1Biotechnology and Biological Sciences Research Council BB/M011186/1Biotechnology and Biological Sciences Research Council BBS/B/0773XBiotechnology and Biological Sciences Research Council BB/V006002/1
6 · The paper itself

Abstract

Ethylene signaling is one of the classic hormonal pathways in plants, with diverse roles in development and stress responses. The dimeric ethylene receptor localizes to the endoplasmic reticulum and contains Cu(I) ions essential for ethylene binding and signal transduction. We previously discovered that mutants of the Arabidopsis gene POLARIS (PLS), encoding a 36-amino-acid peptide, exhibit enhanced ethylene signaling responses suggestive of reduced receptor activity, but the role and activity of the PLS peptide in this signaling cascade have not been defined. Here, we report that Arabidopsis PLS binds copper as a 1:2 thiol-dependent Cu(I):PLS

Indexed as

ArabidopsisArabidopsis ProteinsCopperEthylenesReceptors, Cell SurfaceSignal TransductionGene Expression Regulation, PlantPlant Growth RegulatorsProtein BindingArabidopsis ProteinsCopperethyleneEthylenesETR1 protein, ArabidopsisPlant Growth RegulatorsReceptors, Cell Surfacearabidopsisethylenehormone receptorplant hormone signalingprotein metalation

Identifiers

PMID40574333
PMCPMC12744750

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.