Evidence map›Paper›PMID 40574305›Full record

ArticleAutophagy2025

Sindbis virus is suppressed in the yellow fever mosquito

Sujit Pujhari, Chan C Heu, Marco Brustolin, Rebecca M Johnson, Donghun Kim, Jason L Rasgon

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Autophagy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Sujit PujhariDepartment of Entomology, the Center for Infectious Disease Dynamics, and the Huck Institutes of the Life Sciences, Pennsylvania State University, University Park, PA, USA.
Chan C HeuDepartment of Entomology, the Center for Infectious Disease Dynamics, and the Huck Institutes of the Life Sciences, Pennsylvania State University, University Park, PA, USA.
Marco BrustolinDepartment of Entomology, the Center for Infectious Disease Dynamics, and the Huck Institutes of the Life Sciences, Pennsylvania State University, University Park, PA, USA.
Rebecca M JohnsonDepartment of Entomology, the Center for Infectious Disease Dynamics, and the Huck Institutes of the Life Sciences, Pennsylvania State University, University Park, PA, USA.
Donghun KimDepartment of Entomology, the Center for Infectious Disease Dynamics, and the Huck Institutes of the Life Sciences, Pennsylvania State University, University Park, PA, USA.
Jason L RasgonDepartment of Entomology, the Center for Infectious Disease Dynamics, and the Huck Institutes of the Life Sciences, Pennsylvania State University, University Park, PA, USA.ORCID 0000-0002-4050-8429

Funding

Hologenomic basis of WNV vector competence in Culex tarsalisR01AI150251 · NIAID · PENNSYLVANIA STATE UNIVERSITY, THE · PI RASGON, JASON L · 2019 to 2024
$2.7M
Identification and validation of Zika virus receptor(s) in the midgut lumen of Aedes aegyptiR21AI151475 · NIAID · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI PUJHARI, SUJIT K · 2021 to 2022
$416k
NIAID NIH HHS R01 AI150251NIAID NIH HHS R21 AI151475
6 · The paper itself

Abstract

Macroautophagy/autophagy is a critical modulator of pathogen invasion response in vertebrates and invertebrates. However, how it affects mosquito-borne viral pathogens that significantly burden public health remains relatively underexplored. To address this gap, we use a genetic approach to activate autophagy in the yellow fever mosquito (

Indexed as

AedesAutophagyAutophagy-Related ProteinsBeclin-1Insect ProteinsSindbis VirusYellow FeverAnimalsCell LineAutophagy-Related ProteinsBeclin-1Insect ProteinsArbovirusAtg6autophagosomelipidationmacroautophagyTOR

Identifiers

PMID40574305
PMCPMC12758363

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.