Evidence map›Paper›PMID 40574066›Full record

ReviewPharmaceutics2025

Unraveling Nature's Pharmacy: Transforming Medicinal Plants into Modern Therapeutic Agents.

Natalia Vaou, Chrysoula Chrysa Voidarou, Georgios Rozos, Chrysa Saldari, Elisavet Stavropoulou, Georgia Vrioni, Athanasios Tsakris

Abstract readReview
In one paragraph

Review in Pharmaceutics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Editorial: Natural compounds in veterinary therapeutics.Frontiers in veterinary science · 2026
    Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Natalia VaouDepartment of Microbiology, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece.ORCID 0009-0009-6429-1736
Chrysoula Chrysa VoidarouLaboratory of Animal Health, Hygiene and Food Quality, School of Agriculture, University of Ioannina, 47100 Arta, Greece.ORCID 0000-0002-8035-1710
Georgios RozosLaboratory of Animal Health, Hygiene and Food Quality, School of Agriculture, University of Ioannina, 47100 Arta, Greece.
Chrysa SaldariDepartment of Microbiology, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece.
Elisavet StavropoulouDepartment of Microbiology, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece.
Georgia VrioniDepartment of Microbiology, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece.ORCID 0000-0003-4766-8238
Athanasios TsakrisDepartment of Microbiology, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece.ORCID 0000-0003-0656-4715

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Natural products (NPs) serve as a crucial source for leading bioactive compounds in drug discovery research. Numerous drugs currently utilized as therapeutic agents have been derived from natural origins, with medicinal plant (MP) sources being particularly significant. Despite the advancement of synthetic chemistry, the importance of NPs persists due to their distinct chemical structures and varied biological activities. Moreover, recent advancements in technology have significantly aided in overcoming challenges, primarily due to inherent complexity. This review explores the potential of NPs in the process of drug discovery and development, placing emphasis on the blend of traditional knowledge with modern drug discovery techniques. A brief history of the development of NP drug discovery and examples of significant NPs developed in recent decades are also provided. The focus is on the various methods employed in authentication, selection, extraction/isolation, and bioactivity screening through the application of modern drug-development principles for NPs. Several cutting-edge techniques, such as genetic engineering, metabolic engineering, plant cell culture and synthetic biology utilizing "omics" technologies and computational methodologies enhancing research in NP drug discovery, are also highlighted. There are several problems and inherent challenges regarding NP drug discovery that need to be overcome. Despite the challenges that exist, NPs will be crucial for the future development of new therapeutic drugs, and it is expected that continuous research and the effective utilization of new approaches will further enhance drug discovery efforts.

Indexed as

cutting-edge techniquesdrug developmentdrug discoverymedicinal plantsomics technologiessecondary metabolitestraditional medicine

Identifiers

PMID40574066
PMCPMC12196529

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.