Evidence map›Paper›PMID 40574005›Full record

ArticlePharmaceutics2025

Targeting Neuronal Nitric Oxide Synthase (nNOS) as a Novel Approach to Enhancing the Anti-Melanoma Activity of Immune Checkpoint Inhibitors.

Anika Patel, Shirley Tong, Kate Lozada, Amardeep Awasthi, Richard B Silverman, Jennifer Totonchy, Sun Yang

Abstract read
In one paragraph

Article in Pharmaceutics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Dynamic tail amine interactions drive isoform selectivity for potent human neuronal nitric oxide synthase inhibitors.Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Anika PatelDepartment of Biomedical and Pharmaceutical Sciences, Harry and Diane Rinker Health Science Campus, Chapman University School of Pharmacy, 9401 Jeronimo Road, Irvine, CA 92618, USA.ORCID 0000-0002-5076-6771
Shirley TongDepartment of Biomedical and Pharmaceutical Sciences, Harry and Diane Rinker Health Science Campus, Chapman University School of Pharmacy, 9401 Jeronimo Road, Irvine, CA 92618, USA.ORCID 0000-0001-7026-7905
Kate LozadaDepartment of Biomedical and Pharmaceutical Sciences, Harry and Diane Rinker Health Science Campus, Chapman University School of Pharmacy, 9401 Jeronimo Road, Irvine, CA 92618, USA.
Amardeep AwasthiDepartment of Chemistry, Northwestern University, Evanston, IL 60208, USA.ORCID 0000-0003-3237-9281
Richard B SilvermanDepartment of Chemistry, Northwestern University, Evanston, IL 60208, USA.ORCID 0000-0001-9034-1084
Jennifer TotonchyDepartment of Biomedical and Pharmaceutical Sciences, Harry and Diane Rinker Health Science Campus, Chapman University School of Pharmacy, 9401 Jeronimo Road, Irvine, CA 92618, USA.ORCID 0000-0002-8444-8536
Sun YangDepartment of Pharmacy Practice, Harry and Diane Rinker Health Science Campus, Chapman University School of Pharmacy, 9401 Jeronimo Road, Irvine, CA 92618, USA.ORCID 0000-0002-8463-7468

Funding

Selective inhibition of nitric oxide synthase for multiple indicationsR35GM131788 · NIGMS · NORTHWESTERN UNIVERSITY · PI SILVERMAN, RICHARD B · 2019 to 2023
$2.3M
NIGMS NIH HHS R35 GM131788
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

immune checkpoint inhibitorsinterferon-gamma (IFN-γ)interleukin-2 (IL-2)melanomaneuronal nitric oxide synthase (nNOS)nitric oxide (NO)nNOS inhibitorsperipheral blood mononuclear cells (PBMCs)programmed death-ligand 1 (PD-L1)

Identifiers

PMID40574005
PMCPMC12196278

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.