Evidence map›Paper›PMID 40573963›Full record

ArticleVaccines2025

Evaluation of Peptide-Based Vaccines Against

Ahmed O Shalash, Haolan Sun, Yiru Cui, Jingwen Wang, Barb Arnts, Jannah Bauer, Waleed M Hussein, Zeinab G Khalil, Mariusz Skwarczynski, Istvan Toth

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Vaccines, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ahmed O ShalashSchool of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, QLD 4072, Australia.ORCID 0000-0003-3819-4798
Haolan SunSchool of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, QLD 4072, Australia.
Yiru CuiSchool of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, QLD 4072, Australia.
Jingwen WangSchool of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, QLD 4072, Australia.
Barb ArntsAustralian Institute for Bioengineering and Nanotechnology, The University of Queensland, Biological Resources, Brisbane, QLD 4072, Australia.
Jannah BauerAustralian Institute for Bioengineering and Nanotechnology, The University of Queensland, Biological Resources, Brisbane, QLD 4072, Australia.
Waleed M HusseinInstitute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia.ORCID 0000-0001-5392-1880
Zeinab G KhalilAustralian Institute for Bioengineering and Nanotechnology, The University of Queensland, Biological Resources, Brisbane, QLD 4072, Australia.ORCID 0000-0002-9285-1720
Mariusz SkwarczynskiSchool of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, QLD 4072, Australia.ORCID 0000-0001-7257-807X
Istvan TothSchool of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, QLD 4072, Australia.ORCID 0000-0002-4572-397X

Funding

Australian Research Council DP210101280Australian Research Council FT230100468
6 · The paper itself

Abstract

background

methodsFemale C57BL/6 mice were infected with

resultELISA against the immunizing peptides as coating antigens reflected the immunogenicity, while p145-based ELISA correlated with GAS-specific antibody titres without

conclusionThese findings support the diagnostic utility of p145, NTD, and CTD2 under co-infection settings, and the vaccine potential of J8, NTD, and CTD2, particularly when conjugated to a T helper for enhanced antigen presentation.

Indexed as

Group A Streptococcusimmune response qualityimmunogenicityMutant bacterial strainsnovel antigensS. aureus-infected micevaccines

Identifiers

PMID40573963
PMCPMC12197582

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.