Evidence map›Paper›PMID 40573936›Full record

ReviewVaccines2025

Impact of Chemotherapy on Vaccine Immunogenicity and Revaccination Response of Acute Lymphoblastic Leukemia-A Systematic Review and Meta-Analysis.

Yuyuan Zeng, Chuanyu Yang, Xihan Li, Qi An, Bo Zhou, Wenquan Niu, Yu Tian, Yifei Cheng, Lin Wang

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Vaccines, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yuyuan ZengCapital Institute of Pediatrics, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100020, China.
Chuanyu YangCapital Institute of Pediatrics, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100020, China.
Xihan LiSchool of Public Health, Capital Medical University, Beijing 100069, China.
Qi AnDepartment of Child Health Care, Capital Center for Children's Health, Capital Medical University, Beijing 100020, China.
Bo ZhouDepartment of Child Health Care, Capital Center for Children's Health, Capital Medical University, Beijing 100020, China.
Wenquan NiuCenter for Evidence-Based Medicine, Capital Center for Children's Health, Capital Medical University, Beijing 100020, China.
Yu TianDepartment of Child Health Care, Capital Center for Children's Health, Capital Medical University, Beijing 100020, China.
Yifei ChengPeking University Institute of Hematology, Peking University People's Hospital, Peking University, Beijing 100044, China.
Lin WangDepartment of Child Health Care, Capital Center for Children's Health, Capital Medical University, Beijing 100020, China.ORCID 0000-0001-5536-781X

Funding

Beijing Hospitals Authority Ascent Plan DFL20221103China Medical Board 21-433High-level Public Health Talents Training Plan AL-02-19
6 · The paper itself

Abstract

backgroundChemotherapy, a cornerstone treatment for Acute Lymphoblastic Leukemia (ALL), can compromise immune function, leading to impaired immune memory function and diminished responses to revaccination. This systematic review and meta-analysis sought to evaluate the impact of chemotherapy on the immunogenicity of prior vaccinations and subsequent revaccination responses in children with ALL.

methodsA comprehensive search was conducted through PubMed, Embase, Web of Science, and Medline. Search time was 9 January 2025. R 4.4.2 was employed for data analysis.

resultsA total of 29 relevant studies were identified, with 8 undergoing meta-analysis. The pooled antibody seropositive rates (SPR) for vaccines against Hepatitis B Virus (HBV), Hepatitis A Virus (HAV), diphtheria, tetanus, pertussis, measles, mumps, rubella, varicella, and Pneumococcal Conjugate Vaccine (PCV) demonstrated a statistically significant decline after chemotherapy in ALL patients (

conclusionsThis review provides an updated assessment of this critical topic, representing the first meta-analysis specifically focused on the effects of chemotherapy on different vaccines' immunogenicity in children with ALL.

Indexed as

acute lymphoblastic leukemiaantibodychemotherapyimmunogenicityrevaccination responsevaccine

Identifiers

PMID40573936
PMCPMC12197370

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.