Evidence map›Paper›PMID 40573433›Full record

ArticleViruses2025

Consensus Sequences for

Sven Breitschwerdt, Benedikt Grandel, Benedikt Asbach, Franziska Winter, Todd Allen, Ralf Wagner, Bernd Salzberger, Arne Schneidewind

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Viruses, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Sven BreitschwerdtDepartment of Internal Medicine I, University Hospital Regensburg, 93053 Regensburg, Germany.
Benedikt GrandelDepartment of Internal Medicine I, University Hospital Regensburg, 93053 Regensburg, Germany.
Benedikt AsbachInstitute of Medical Microbiology and Hygiene, University Regensburg, 93053 Regensburg, Germany.ORCID 0000-0003-1056-8591
Franziska WinterDepartment of Internal Medicine I, University Hospital Regensburg, 93053 Regensburg, Germany.
Todd AllenThe Ragon Institute of MGH, MIT and Harvard, Boston, MA 02139, USA.
Ralf WagnerInstitute of Medical Microbiology and Hygiene, University Regensburg, 93053 Regensburg, Germany.
Bernd SalzbergerDepartment of Internal Medicine I, University Hospital Regensburg, 93053 Regensburg, Germany.
Arne SchneidewindDepartment of Internal Medicine I, University Hospital Regensburg, 93053 Regensburg, Germany.

Funding

Deutsche Forschungsgemeinschaft DFG SCHN1085-2-1University of Regensburg Doctoral Scholarship
6 · The paper itself

Abstract

Viral evasion from effective human immunodeficiency virus type 1 (HIV-1)-specific CD8+ T-cell responses and from antiretroviral therapy through viral sequence variation is frequently accompanied by a loss in viral fitness. The impact of sequence variations on replication capacity in vitro was mostly studied by introducing single mutations into a specific clonal strain such as NL4-3. How the specific viral backbone itself impacts replicative fitness remains elusive. To test for a potential effect of the viral backbone, we constructed HIV-1 clade B clones with consensus sequences for

Indexed as

Consensus SequenceDrug Resistance, Viralgag Gene Products, Human Immunodeficiency VirusHIV-1Immune EvasionPoint Mutationpol Gene Products, Human Immunodeficiency VirusVirus ReplicationHIV InfectionsHumansT-Lymphocytes, Cytotoxicgag Gene Products, Human Immunodeficiency Viruspol Gene Products, Human Immunodeficiency Virusconsensus sequencedrug resistanceHIVimmune escapereplication capacityviral backbone

Identifiers

PMID40573433
PMCPMC12197770

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.