Evidence map›Paper›PMID 40573425›Full record

ReviewViruses2025

The Role of Bacteriophage-Derived Small RNA Molecules in Bacterial and Phage Interactions.

Natalia Lewandowska, Sylwia Bloch, Aleksandra Łukasiak, Wojciech Wesołowski, Grzegorz Węgrzyn, Bożena Nejman-Faleńczyk

Abstract readReview
In one paragraph

Review in Viruses, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. A 3'UTR-derived small RNA modulates the life cycle of the cholera toxin-encoding filamentous phage, CTXϕ.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Natalia LewandowskaLaboratory of Biology and Biotechnology of Bacteriophages, Department of Molecular Biology, Faculty of Biology, University of Gdańsk, Wita Stwosza 59, 80-308 Gdansk, Poland.
Sylwia BlochLaboratory of Biology and Biotechnology of Bacteriophages, Department of Molecular Biology, Faculty of Biology, University of Gdańsk, Wita Stwosza 59, 80-308 Gdansk, Poland.
Aleksandra ŁukasiakLaboratory of Biology and Biotechnology of Bacteriophages, Department of Molecular Biology, Faculty of Biology, University of Gdańsk, Wita Stwosza 59, 80-308 Gdansk, Poland.ORCID 0000-0002-5202-4261
Wojciech WesołowskiLaboratory of Biology and Biotechnology of Bacteriophages, Department of Molecular Biology, Faculty of Biology, University of Gdańsk, Wita Stwosza 59, 80-308 Gdansk, Poland.ORCID 0000-0003-4631-0648
Grzegorz WęgrzynLaboratory of Biology and Biotechnology of Bacteriophages, Department of Molecular Biology, Faculty of Biology, University of Gdańsk, Wita Stwosza 59, 80-308 Gdansk, Poland.ORCID 0000-0003-4042-7466
Bożena Nejman-FaleńczykLaboratory of Biology and Biotechnology of Bacteriophages, Department of Molecular Biology, Faculty of Biology, University of Gdańsk, Wita Stwosza 59, 80-308 Gdansk, Poland.ORCID 0000-0003-4468-0733

Funding

National Science Center 2018/29/B/NZ1/00549National Science Center 2018/30/E/NZ1/00400
6 · The paper itself

Abstract

Small regulatory RNAs (sRNAs) play a critical role in bacterial gene expression, modulating various cellular processes, including stress responses, metabolism, virulence, and many others. While well-characterized in bacterial systems, an emerging class of phage-derived sRNAs has been identified, suggesting an underexplored regulatory network at phage-host interactions. These sRNAs, encoded within phage genomes, influence both bacterial and viral life cycles by modulating transcriptional and post-transcriptional gene expression processes. The interplay between phage-derived sRNAs and the host genome reveals a complex network of gene regulation, with an impact on bacterial fitness, pathogenesis, and horizontal gene transfer. This review explores the diverse functions of phage-encoded sRNAs, highlighting recent discoveries and their impact on bacterial physiology and phage-host interactions.

Indexed as

BacteriaBacteriophagesHost Microbial InteractionsRNA, Small UntranslatedRNA, ViralGene Expression Regulation, BacterialGene Transfer, HorizontalHost-Pathogen InteractionsRNA, BacterialRNA, BacterialRNA, Small UntranslatedRNA, Viralbacteriophagesbacteriophage sRNAsmicroRNAsmall regulatory RNAs

Identifiers

PMID40573425
PMCPMC12197685

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.