Evidence map›Paper›PMID 40573405›Full record

ArticleViruses2025

Discovery of Small-Molecule Inhibitors Against Norovirus 3CL

Hao Shen, Shiqi Liu, Limin Shang, Yuchen Liu, Yijin Sha, Dingwei Lei, Yuehui Zhang, Chaozhi Jin, Shanshan Wu, Mingyang Zhang and 3 more

Abstract read
In one paragraph

Article in Viruses, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Hao ShenSchool of Basic Medical Sciences, Anhui Medical University, Hefei 230032, China.
Shiqi LiuSchool of Basic Medical Sciences, Anhui Medical University, Hefei 230032, China.
Limin ShangState Key Laboratory of Medical Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Beijing Institute of Lifeomics, Beijing 102206, China.
Yuchen LiuState Key Laboratory of Medical Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Beijing Institute of Lifeomics, Beijing 102206, China.
Yijin ShaSchool of Basic Medical Sciences, Anhui Medical University, Hefei 230032, China.
Dingwei LeiSchool of Pharmaceutical Sciences, Peking University, Beijing 100091, China.
Yuehui ZhangState Key Laboratory of Medical Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Beijing Institute of Lifeomics, Beijing 102206, China.
Chaozhi JinState Key Laboratory of Medical Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Beijing Institute of Lifeomics, Beijing 102206, China.
Shanshan WuState Key Laboratory of Medical Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Beijing Institute of Lifeomics, Beijing 102206, China.
Mingyang ZhangState Key Laboratory of Medical Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Beijing Institute of Lifeomics, Beijing 102206, China.ORCID 0000-0002-3513-7766
Han WenAI for Science Institute, Beijing 100085, China.
Chenxi JiaSchool of Basic Medical Sciences, Anhui Medical University, Hefei 230032, China.
Jian WangSchool of Basic Medical Sciences, Anhui Medical University, Hefei 230032, China.ORCID 0000-0002-8116-7691

Funding

Guangzhou National Laboratory GZNL202301004
6 · The paper itself

Abstract

Norovirus, a major cause of acute gastroenteritis, possesses a single-stranded positive-sense RNA genome. The viral 3C-like cysteine protease (3CL

Indexed as

Antiviral AgentsCysteine EndopeptidasesNorovirusSmall Molecule LibrariesViral Proteins3C Viral ProteasesCaliciviridae InfectionsDrug DiscoveryDrug Evaluation, PreclinicalHumansMolecular Docking SimulationMolecular Dynamics SimulationVirus Replication3C Viral ProteasesAntiviral AgentsCysteine EndopeptidasesSmall Molecule LibrariesViral Proteins3C-like protease (3CLpro)antiviral drug discoveryFlipGFP assaymolecular docking and dynamicsnorovirusvirtual screening

Identifiers

PMID40573405
PMCPMC12197363

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.