Evidence map›Paper›PMID 40573374›Full record

ArticleViruses2025

SARS-CoV-2 (MA10) Infection Aggravates Cerebrovascular Pathology in Endothelial Nitric Oxide Synthase-Deficient Mice.

Saifudeen Ismael, Meenakshi Umar, Blake Ouvrier, Gregory Hall, McKenzie Cummins, Arjun Sapkota, Grant Talkington, Amanda Louise White, Richard Milner, Damir B Khismatullin and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Viruses, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Saifudeen IsmaelDepartment of Neurosurgery, Clinical Neuroscience Research Center, School of Medicine, Tulane University, New Orleans, LA 70112, USA.ORCID 0000-0001-9976-0939
Meenakshi UmarDepartment of Neurosurgery, Clinical Neuroscience Research Center, School of Medicine, Tulane University, New Orleans, LA 70112, USA.
Blake OuvrierDepartment of Neurosurgery, Clinical Neuroscience Research Center, School of Medicine, Tulane University, New Orleans, LA 70112, USA.
Gregory HallDepartment of Neurosurgery, Clinical Neuroscience Research Center, School of Medicine, Tulane University, New Orleans, LA 70112, USA.
McKenzie CumminsDepartment of Biomedical Engineering, Tulane University, New Orleans, LA 70118, USA.ORCID 0009-0001-8852-9675
Arjun SapkotaSan Diego Biomedical Research Institute, San Diego, CA 92121, USA.
Grant TalkingtonDepartment of Neurosurgery, Clinical Neuroscience Research Center, School of Medicine, Tulane University, New Orleans, LA 70112, USA.
Amanda Louise WhiteDepartment of Neurosurgery, Clinical Neuroscience Research Center, School of Medicine, Tulane University, New Orleans, LA 70112, USA.ORCID 0000-0003-4858-0860
Richard MilnerSan Diego Biomedical Research Institute, San Diego, CA 92121, USA.
Damir B KhismatullinDepartment of Biomedical Engineering, Tulane University, New Orleans, LA 70118, USA.ORCID 0000-0002-7533-8132
Gregory BixDepartment of Neurosurgery, Clinical Neuroscience Research Center, School of Medicine, Tulane University, New Orleans, LA 70112, USA.ORCID 0000-0002-8969-9553

Funding

Investigating the role of Alpha5Beta1 integrin in cognitive dysfunctionRF1AG078677 · NIA · TULANE UNIVERSITY OF LOUISIANA · PI BIX, GREGORY JAYE, BURANDA, TIONE · 2023 to 2024
$2.4M
Drop-of-blood technology for diagnosis and therapeutic drug monitoring in patients with infectious diseaseR21EB031401 · NIBIB · TULANE UNIVERSITY OF LOUISIANA · PI KHISMATULLIN, DAMIR B · 2022 to 2024
$597k
American Heart Association 24CDA1262486NIBIB NIH HHS R21 EB031401NIH HHS 1RF1NS136861-27A1NIH HHS RF1AG078677
6 · The paper itself

Abstract

SARS-CoV-2 can cause neurological issues, including cognitive dysfunction in COVID-19 survivors. Endothelial dysfunction, a key mechanism in COVID-19, is also a risk factor for vascular dementia (VaD). Reduced nitric oxide (NO) bioavailability is a pathogenic factor of endothelial dysfunction and platelet aggregation in COVID-19 patients, and endothelial NO synthase (eNOS) levels decline with advancing age, a risk factor for both COVID-19 morbidity and VaD. SARS-CoV-2 also induces cellular senescence and senescence-associated secretory phenotype (SASP). We hypothesized that eNOS deficiency would worsen neuroinflammation, senescence, blood-brain barrier (BBB) permeability, and hypercoagulability in eNOS-deficient mice. Six-month-old eNOS

Indexed as

COVID-19Nitric Oxide Synthase Type IIISARS-CoV-2AnimalsBlood-Brain BarrierBrainCellular SenescenceDementia, VascularDisease Models, AnimalInflammationMaleMiceMice, Inbred C57BLMice, KnockoutViral LoadNitric Oxide Synthase Type IIINos3 protein, mouseendothelial nitric oxide synthaseneuroinflammationSARS-CoV-2senescencevascular dementia

Identifiers

PMID40573374
PMCPMC12197800

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.