Evidence map›Paper›PMID 40573353›Full record

ArticleViruses2025

Comparative Analysis of Two Zika Virus Isolates in a Rhesus Macaque Pregnancy Model.

Hannah K Jaeger, Jessica L Smith, Christopher J Parkins, Nicole N Haese, Craig N Kreklywich, Michael Denton, Caralyn S Labriola, Michael K Axthelm, Aaron Barber-Axthelm, Kim Chun and 8 more

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Viruses, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Hannah K JaegerThe Vaccine & Gene Therapy Institute, Oregon Health and Science University, Beaverton, OR 97006, USA.ORCID 0000-0003-3285-2139
Jessica L SmithThe Vaccine & Gene Therapy Institute, Oregon Health and Science University, Beaverton, OR 97006, USA.ORCID 0000-0002-8314-7141
Christopher J ParkinsThe Vaccine & Gene Therapy Institute, Oregon Health and Science University, Beaverton, OR 97006, USA.
Nicole N HaeseThe Vaccine & Gene Therapy Institute, Oregon Health and Science University, Beaverton, OR 97006, USA.
Craig N KreklywichThe Vaccine & Gene Therapy Institute, Oregon Health and Science University, Beaverton, OR 97006, USA.
Michael DentonThe Vaccine & Gene Therapy Institute, Oregon Health and Science University, Beaverton, OR 97006, USA.
Caralyn S LabriolaThe Vaccine & Gene Therapy Institute, Oregon Health and Science University, Beaverton, OR 97006, USA.ORCID 0000-0002-8271-6242
Michael K AxthelmThe Vaccine & Gene Therapy Institute, Oregon Health and Science University, Beaverton, OR 97006, USA.ORCID 0000-0002-1984-5906
Aaron Barber-AxthelmDivision of Pathobiology & Immunology, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR 97006, USA.
Kim ChunDivision of Pathobiology & Immunology, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR 97006, USA.
Tonya SwansonDivision of Pathobiology & Immunology, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR 97006, USA.
Rahul J D'MelloDivision of Reproductive & Developmental Sciences, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR 97006, USA.ORCID 0000-0001-8343-0572
Terry K MorganDepartment of Obstetrics & Gynecology, Oregon Health & Science University, Portland, OR 97239, USA.
Duncan R SmithInstitute of Molecular Biosciences, Mahidol University, Salaya Campus, 25/25 Phuttamonthol Sai 4, Nakhon Pathom 73170, Thailand.ORCID 0000-0002-6592-9852
Jamie O LoDivision of Reproductive & Developmental Sciences, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR 97006, USA.ORCID 0000-0002-1934-1935
Alec J HirschThe Vaccine & Gene Therapy Institute, Oregon Health and Science University, Beaverton, OR 97006, USA.
Victoria H J RobertsDivision of Reproductive & Developmental Sciences, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR 97006, USA.ORCID 0000-0002-1553-3702
Daniel N StreblowThe Vaccine & Gene Therapy Institute, Oregon Health and Science University, Beaverton, OR 97006, USA.ORCID 0000-0002-6828-2492

Funding

Upgrade of confocal microscopy at the Oregon National Primate Research CenterP51OD011092 · OD · OREGON HEALTH & SCIENCE UNIVERSITY · PI Bonnie J. Nagel · 2012 to 2026
$203.9M
REPRODUCTIVE SCIENTIST TRAINING PROGRAMK12HD000849 · NICHD · WASHINGTON UNIVERSITY · PI Danny J Schust · 1988 to 2026
$33.2M
Mechanistic Analysis of Zika Virus Induced Placental Damage During PregnancyR01HD096741 · NICHD · OREGON HEALTH & SCIENCE UNIVERSITY · PI LO, JAMIE, STREBLOW, DANIEL N · 2019 to 2023
$3.3M
Development of a NHP model for determining the causal relationship between Zika virus infection during pregnancy and fetal microcephaly.R21HD091032 · NICHD · OREGON HEALTH & SCIENCE UNIVERSITY · PI STREBLOW, DANIEL N · 2016 to 2017
$481k
NICHD NIH HHS K12 HD000849NICHD NIH HHS R01 HD096741NICHD NIH HHS R21 HD091032NIH HHS 1P51TW011092-02A2NIH HHS 1R01HD096741-05A5NIH HHS 1R21HD091032-02A1NIH HHS P51 OD011092
6 · The paper itself

Abstract

Zika virus (ZIKV) infection during pregnancy can cause a broad range of neurological birth defects, collectively named Congenital Zika Syndrome (CZS). We have previously shown that infection with the Puerto Rican isolate PRVABC59 (ZIKV-PR) results in abnormal oxygen transport in the placenta due to villous damage and uterine vasculitis in a nonhuman primate model. To investigate whether this type of damage occurs with endemically circulating strains in Thailand, we investigated a CZS case isolate, MU1-2017 (ZIKV-TH), in pregnant rhesus macaques. Pregnant animals (

Indexed as

Pregnancy Complications, InfectiousZika VirusZika Virus InfectionAnimalsDisease Models, AnimalFemaleMacaca mulattaPlacentaPregnancyRNA, ViralThailandViremiaRNA, Viralcongenital Zika syndromeimmunologynon-human primateplacentaThailandZika virus

Identifiers

PMID40573353
PMCPMC12197658

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.