ArticleViruses2025
Relationship Between Estimated Drug Distribution of Antiretroviral Therapy and Immune Proteins in Cerebrospinal Fluid During Chronic HIV Suppression.
Mattia Trunfio, Jennifer E Iudicello, Patricia K Riggs, Asha R Kallianpur, Todd Hulgan, Ronald J Ellis, Scott L Letendre
Abstract read
In one paragraphArticle in Viruses, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
7 authors.
Mattia TrunfioHIV Neurobehavioral Research Program, Departments of Neurosciences and Psychiatry, University of California, 220 Dickinson St., San Diego, CA 92103, USA.
Jennifer E IudicelloHIV Neurobehavioral Research Program, Departments of Neurosciences and Psychiatry, University of California, 220 Dickinson St., San Diego, CA 92103, USA.
Patricia K RiggsHIV Neurobehavioral Research Program, Departments of Neurosciences and Psychiatry, University of California, 220 Dickinson St., San Diego, CA 92103, USA.
Asha R KallianpurDepartment of Genomic Medicine, Cleveland Clinic Lerner Research Institute, Cleveland, OH 44106, USA.ORCID 0000-0002-6483-523X Todd HulganDepartment of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Ronald J EllisHIV Neurobehavioral Research Program, Departments of Neurosciences and Psychiatry, University of California, 220 Dickinson St., San Diego, CA 92103, USA.ORCID 0000-0003-4931-752X Scott L LetendreHIV Neurobehavioral Research Program, Departments of Neurosciences and Psychiatry, University of California, 220 Dickinson St., San Diego, CA 92103, USA.
Funding
STRUCTURAL NEUROIMAGING COREP30MH062512 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Jessica Lynette Montoya · 2001 to 2026
$50.4MCHARTER Plus: A resource for cutting-edge research on neurological function and mental health in people with HIV and substance use disorders across the lifespanR24MH129166 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI RONALD J. ELLIS, Scott L Letendre · 2022 to 2026
$9.9MBiopsychosocial Phenotypes and Potential Mechanisms in CHARTERR01MH125720 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ELLIS, RONALD J., LETENDRE, SCOTT L · 2021 to 2025
$3.7MIron and Mitochondrial Genomics in Neuro-inflammation and HAND: A CHARTER StudyR01MH095621 · NIMH · VANDERBILT UNIVERSITY MEDICAL CENTER · PI HULGAN, TODD M, KALLIANPUR, ASHA R · 2011 to 2015
$3.1MNIMH NIH HHS P30 MH062512NIMH NIH HHS P30MH062512, R24MH129166, R01MH125720, R01MH095621NIMH NIH HHS R01 MH095621NIMH NIH HHS R01 MH125720NIMH NIH HHS R24 MH129166
6 · The paper itselfAbstract
Antiretroviral therapy (ART) drugs vary in their distribution into cerebrospinal fluid (CSF), which can be estimated using the central nervous system (CNS) penetration effectiveness (CPE) score. Although higher CPE has been associated with lower CSF HIV RNA levels, its relationship to CSF inflammation is less clear. We investigated associations between CPE and three CSF immune biomarkers (CXCL10, TNF-α, and IL-6) in 275 virally suppressed people with HIV (PWH) on three-drug ART regimens using a training-validation design. Participants were randomized into training (TG, n = 144) and validation (VG, n = 131) groups with similar demographics, ART characteristics, and CPE scores. The CSF levels of the biomarkers were quantified by bead suspension array-based immunoassays. In both groups, higher CPE correlated with lower levels of CXCL10 (TG: r = -0.31,
Indexed as
Anti-HIV AgentsAnti-Retroviral AgentsHIV InfectionsAdultBiomarkersCerebrospinal FluidChemokine CXCL10FemaleHumansInterleukin-6MaleMiddle AgedTumor Necrosis Factor-alphaViral LoadAnti-HIV AgentsAnti-Retroviral AgentsBiomarkersChemokine CXCL10CXCL10 protein, humanIL6 protein, humanInterleukin-6Tumor Necrosis Factor-alphaantiretroviralscentral nervous system penetration efficacychronic neuroinflammationCPECXCL10IL-6neuro HIVneurotargeted antiretroviral therapyTNF-α
Identifiers
PMID40573339
PMCPMC12197675
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390