Evidence map›Paper›PMID 40573320›Full record

ArticlePharmaceuticals (Basel, Switzerland)2025

3D-QSAR Design of New Bcr-Abl Inhibitors Based on Purine Scaffold and Cytotoxicity Studies on CML Cell Lines Sensitive and Resistant to Imatinib.

David Cabezas, Thalía Delgado, Guisselle Sepúlveda, Petra Krňávková, Veronika Vojáčková, Vladimír Kryštof, Miroslav Strnad, Nicolás Ignacio Silva, Javier Echeverría, Christian Espinosa-Bustos and 4 more

Abstract read
In one paragraph

Article in Pharmaceuticals (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Advances in Targeting BCR-ABLMolecules (Basel, Switzerland) · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

David CabezasInstituto de Química, Facultad de Ciencias, Universidad de Valparaíso, Valparaíso 2360102, Chile.ORCID 0000-0002-4040-1306
Thalía DelgadoDepartamento de Química Orgánica, Facultad de Química y de Farmacia, Pontificia Universidad Católica de Chile, Santiago de Chile 7820436, Chile.ORCID 0000-0001-8189-0022
Guisselle SepúlvedaDepartamento de Química Orgánica, Facultad de Química y de Farmacia, Pontificia Universidad Católica de Chile, Santiago de Chile 7820436, Chile.
Petra KrňávkováDepartment of Experimental Biology, Palacký University, Slechtitelu 27, 77900 Olomouc, Czech Republic.ORCID 0009-0005-3578-6386
Veronika VojáčkováDepartment of Experimental Biology, Palacký University, Slechtitelu 27, 77900 Olomouc, Czech Republic.
Vladimír KryštofDepartment of Experimental Biology, Palacký University, Slechtitelu 27, 77900 Olomouc, Czech Republic.ORCID 0000-0001-5838-2118
Miroslav StrnadLaboratory of Growth Regulators, Palacký University and Institute of Experimental Botany, The Czech Academy of Sciences, Slechtitelu 27, 77900 Olomouc, Czech Republic.
Nicolás Ignacio SilvaDepartamento de Química Orgánica, Facultad de Química y de Farmacia, Pontificia Universidad Católica de Chile, Santiago de Chile 7820436, Chile.ORCID 0009-0006-5084-3630
Javier EcheverríaDepartamento de Ciencias del Ambiente, Facultad de Química y Biología, Universidad de Santiago de Chile, Santiago de Chile 9170022, Chile.ORCID 0000-0002-1688-968X
Christian Espinosa-BustosDepartamento de Farmacia, Facultad de Química y de Farmacia, Pontificia Universidad Católica de Chile, Santiago de Chile 7820436, Chile.ORCID 0000-0001-6038-8439
Guido MelladoDepartamento de Ingeniería Informática, Facultad de Ingeniería, Universidad Católica de Temuco, Temuco 4780000, Chile.ORCID 0000-0003-0792-7733
Jiao LuoInstituto de Química, Facultad de Ciencias, Universidad de Valparaíso, Valparaíso 2360102, Chile.
Jaime MellaInstituto de Química, Facultad de Ciencias, Universidad de Valparaíso, Valparaíso 2360102, Chile.ORCID 0000-0002-2434-8461
Cristian O SalasDepartamento de Química Orgánica, Facultad de Química y de Farmacia, Pontificia Universidad Católica de Chile, Santiago de Chile 7820436, Chile.ORCID 0000-0001-7620-2459

Funding

Czech Science Foundation 23-05474SEuropean Union - Next Generation EU ID No. LX22NPO5102Fondo Nacional de Desarrollo Científico y Tecnológico 1231199Palacký University Olomouc IGA_PrF_20242025_005011
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

3D-QSARBcr-Abl inhibitorschronic myeloid leukaemiadocking studiesmolecular dynamicspurine derivatives

Identifiers

PMID40573320
PMCPMC12195648

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.