ArticleMaterials (Basel, Switzerland)2025
Towards a Sustainable Material Protection: Olanzapine Drugs and Their Derivatives as Corrosion Inhibitors for C1018 Steel in 1 M Hydrochloric Acid.
Article in Materials (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
This study investigates the synthesis process and characterization methods and evaluates the inhibition behavior of olanzapine (2-methyl-4-(4-methyl-1-piperazinyl)-10H-thieno-[2,3-b] 1,5]benzodiazepine (OLZ)) and its derivatives, such as 3-(2-methyl-4-(4-methylpiperazin-1-yl)-10H-benzo[b]thieno[2,3-e] [1,4]diazepin-10-yl) propenamide (OLZ1) and Ethyl 2-(2-methyl-4-(4-methylpiperazin-1-yl)-10H-benzo[b]thieno[2,3-e][1,4]diazepin-10 yl) acetate (OLZ2) for carbon steel (C1018) in a 1 M HCl acidic solution. Fourier Transform Infrared Spectroscopy (FTIR) and Nuclear Magnetic Resonance (NMR) were employed to verify their molecular structures and functional groups, which characterized the derivatives after synthesis. Their corrosion inhibition potential for C1018 steel in acidic media was estimated by weight loss (WL) and electrochemical techniques, such as electrochemical impedance spectroscopy (EIS), linear polarization resistance (LPR), and potentiodynamic polarization (PDP), accompanied by surface analysis methods. The findings revealed that all three derivatives demonstrated exceptional inhibition performance, achieving maximum efficiencies of 88.83%, 91.20%, and 91.82% for OLZ, OLZ1, and OLZ2 at 300 ppm, respectively. Weight loss experiments across different temperatures further explored their inhibitory behavior. Although inhibition efficiency decreased with a temperature increase to 318 K, the derivatives still displayed notable performance, with maximum efficiencies of 74.75% for OLZ, 81.63% for OLZ1, and 79.44% for OLZ2. Polarization studies identified the corrosion inhibition mechanisms as an anodic type. Surface characterization of the C1018 steel coupons, both with and without the inhibitors, was performed using FTIR and scanning electron microscopy (SEM) combined with energy-dispersive X-ray spectroscopy (EDX). These analyses indicated the creation of a protective inhibitor layer on the carbon steel surface, reducing corrosion in the acidic environment. Overall, this study underscores the potential of these drug derivatives as corrosion inhibitors, combining structural insights and performance assessments to support their industrial application.
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