Evidence map›Paper›PMID 40572742›Full record

ReviewMedicina (Kaunas, Lithuania)2025

Mammalian PI-Phospholipase C Isozymes: Structural and Functional Insights and Roles in Health and Disease.

May Hamdi, Mohammed Al-Matwi, Nour Elghoul, Hissa Al-Kuwari, Tahseen S Sayed, Emna Riguene, Michail Nomikos

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Medicina (Kaunas, Lithuania), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

May HamdiCollege of Medicine, QU Health, Qatar University, Doha P.O. Box 2713, Qatar.
Mohammed Al-MatwiCollege of Medicine, QU Health, Qatar University, Doha P.O. Box 2713, Qatar.
Nour ElghoulCollege of Medicine, QU Health, Qatar University, Doha P.O. Box 2713, Qatar.
Hissa Al-KuwariCollege of Medicine, QU Health, Qatar University, Doha P.O. Box 2713, Qatar.ORCID 0009-0004-0160-2684
Tahseen S SayedCollege of Medicine, QU Health, Qatar University, Doha P.O. Box 2713, Qatar.
Emna RigueneCollege of Medicine, QU Health, Qatar University, Doha P.O. Box 2713, Qatar.
Michail NomikosCollege of Medicine, QU Health, Qatar University, Doha P.O. Box 2713, Qatar.

Funding

QATAR UNIVERSITY QUST-1-CMED-2025-278
6 · The paper itself

Abstract

The Phosphoinositide Specific-Phospholipase C (PI-PLC) family of enzymes plays a crucial role in various cellular processes by catalyzing the hydrolysis of phosphatidylinositol 4,5-bisphosphate [PI(4,5)P

Indexed as

Phosphoinositide Phospholipase CAnimalsHumansIsoenzymesSignal TransductionIsoenzymesPhosphoinositide Phospholipase CCalcium Signalingcancercatalytic activityinfertilityphosphoinositide metabolismPhosphoinositide Specific-Phospholipase C Isoformstherapeutic targets

Identifiers

PMID40572742
PMCPMC12195575

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.