Evidence map›Paper›PMID 40572628›Full record

ArticleMolecules (Basel, Switzerland)2025

Enhancing the Pharmacological Properties of Triterpenes Through Acetylation: An Anticancer and Antioxidant Perspective.

Barbara Bednarczyk-Cwynar, Piotr Ruszkowski, Andrzej Günther, Szymon Sip, Katarzyna Bednarek-Rajewska, Przemysław Zalewski

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Unraveling the Effects ofInternational journal of molecular sciences · 2025
    Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Barbara Bednarczyk-CwynarDepartment of Organic Chemistry, Faculty of Pharmacy, Poznan University of Medical Sciences, Collegium Pharmaceuticum 2, (CP.2), Rokietnicka Str. 3, 60-806 Poznan, Poland.ORCID 0000-0003-2958-9106
Piotr RuszkowskiDepartment of Pharmacology, Faculty of Pharmacy, Poznan University of Medical Sciences, Collegium Pharmaceuticum 1 (CP.1), Rokietnicka Str. 3, 60-806 Poznan, Poland.ORCID 0000-0002-5106-8510
Andrzej GüntherDepartment of Organic Chemistry, Faculty of Pharmacy, Poznan University of Medical Sciences, Collegium Pharmaceuticum 2, (CP.2), Rokietnicka Str. 3, 60-806 Poznan, Poland.ORCID 0000-0002-4492-6329
Szymon SipDepartment of Pharmacognosy and Biomaterials, Faculty of Pharmacy, Poznan University of Medical Sciences, Collegium Pharmaceuticum 1 (CP.1), Rokietnicka Str. 3, 60-806 Poznan, Poland.ORCID 0000-0002-6618-9956
Katarzyna Bednarek-RajewskaDepartment of Clinical Pathology, Faculty of Medical Sciences, Poznan University of Medical Sciences, Przybyszewskiego Str. 49, 60-355 Poznan, Poland.
Przemysław ZalewskiDepartment of Pharmacognosy and Biomaterials, Faculty of Pharmacy, Poznan University of Medical Sciences, Collegium Pharmaceuticum 1 (CP.1), Rokietnicka Str. 3, 60-806 Poznan, Poland.ORCID 0000-0002-5116-9426

Funding

Poznan University of Medical Sciences
6 · The paper itself

Abstract

This paper presents the influence of acetylation on the cytotoxic and antioxidant activity of natural triterpenes. Oleanolic acid, betulin, betulinic acid and other triterpenes have been modified to improve their pharmacological properties. Acylation of the hydroxyl group at the C-3 position showed significant changes in biological activity, in particular against cancer cell lines such as HeLa, A-549, MCF-7, PC-3 and SKOV-3, with the highest IC

Indexed as

Antineoplastic AgentsAntioxidantsTriterpenesAcetylationBetulinic AcidCell Line, TumorHumansMCF-7 CellsMolecular Docking SimulationOleanolic AcidStructure-Activity RelationshipAntineoplastic AgentsAntioxidantsBetulinic AcidOleanolic AcidTriterpenesacyl derivatives of triterpenesADMEToxallobetulinantioxidant activitybetulinbetulinic acidcytotoxic activityerythrodiollupeolmolecular dockingoleanolic acidSARSelectivity Index

Identifiers

PMID40572628
PMCPMC12196235

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.