Synthesis of 1-(2-Hydroxy-5-methylphenyl)-5-oxopyrrolidine-3-carboxylic Acid Derivatives as a Promising Scaffold Against Disease-Causing Bacteria Relevant to Public Health.

Karolis Krikštaponis, Jūratė Šiugždaitė, Rita Vaickelionienė, Vytautas Mickevičius, Birutė Grybaitė

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Article in Molecules (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed

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1 · What the graph read from it

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2 · The registry

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Karolis KrikštaponisDepartment of Organic Chemistry, Kaunas University of Technology, 50254 Kaunas, Lithuania.

Jūratė ŠiugždaitėDepartment of Veterinary Pathobiology, Lithuanian University of Health Sciences, 47181 Kaunas, Lithuania.ORCID 0009-0004-7523-2698

Rita VaickelionienėDepartment of Organic Chemistry, Kaunas University of Technology, 50254 Kaunas, Lithuania.

Vytautas MickevičiusDepartment of Organic Chemistry, Kaunas University of Technology, 50254 Kaunas, Lithuania.ORCID 0000-0002-9961-2941

Birutė GrybaitėDepartment of Organic Chemistry, Kaunas University of Technology, 50254 Kaunas, Lithuania.ORCID 0000-0003-0982-1342

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The increasing number of antibiotic-resistant pathogens forces us to accelerate the search for new antimicrobial agents. Based on this, we chose to synthesize a library of 1-(2-hydroxy-5-methylphenyl)-5-oxopyrrolidine-3-carboxylic acid derivatives and evaluate their antibacterial activity against various pathogens. A series of (2-hydroxy-5-methylphenyl)-5-oxopyrrolidine-3-carboxylic acid and its hydrazide derivatives were prepared and identified by the methods of IR,

Indexed as

Anti-Bacterial AgentsBacteriaCarboxylic AcidsPyrrolidinesBacillus cereusEscherichia coliListeria monocytogenesMicrobial Sensitivity TestsMolecular StructureStaphylococcus aureusStructure-Activity RelationshipAnti-Bacterial AgentsCarboxylic AcidsPyrrolidines5-oxopyrrolidineantibacterial activitybiofilm formationheterocycleshydrazone

Identifiers

PMID40572602

DOI10.3390/molecules30122639

PMCPMC12196313

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LicenceCC BY

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.